Clearance of Hepatitis B virus from Chronic Carrier by Oriental Medicine Treatments

  • Son, Chang-Gue (Department of Internal Medicine, Oriental Medical College, Daejeon University)
  • Published : 2009.05.30

Abstract

Objective : To study the Oriental Medicine-based strategies or therapeutics for chronic HBV infection. Methods : A chronic HBV carrier was treated with only oriental therapies. Then, serum biochemical parameters were serially chased, and change of HBV-DNA level was evaluated. Result : The biochemical indicators (AST, ALT, gamma-GTP, bilirubin) fluctuated during the treatment period. After one episode of drastic elevation of serum aminotransferase, HBV-DNA disappeared from the blood along with normalization of biochemical parameters within two years of beginning treatment. Conclusion : Oriental Medicine-based therapeutics could be an alternative strategy against chronic infection of HBV.

Keywords

References

  1. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997;337:1733-45. https://doi.org/10.1056/NEJM199712113372406
  2. de Franchis R, Hadengue A, Lau G, Lavanchy D, Lok A, McIntyre N, et al. EASL International Consensus Conference on Hepatitis B. J Hepatol. 2003;39:S3-25.
  3. de Franchis R, Hadengue A, Lau G, Lavanchy D, Lok A, McIntyre N, et al. EASL International Consensus Conference on Hepatitis B. J Hepatol. 2003;39:S3-25.
  4. Han KH, Kim JK. Liver cancer in Korea. Hepatol Res. 2007;37:S106-9. https://doi.org/10.1111/j.1872-034X.2007.00171.x
  5. Shao ZJ, Xu DZ, Xu JQ, Li JH, Yan YP, Men K, et al. Maternal hepatitis B virus DNA positivity and sexual intercourse are associated with HBV intrauterine transmissionin China: a prospective case-control study. J Gastroenterol Hepatol. 2007 ;22:165-70. https://doi.org/10.1111/j.1440-1746.2006.04462.x
  6. KNSO, Koean motality and causes of death in 2003. 2004.
  7. Leemans WF, Janssen HL, de Man RA. Future prospectives for the management of chronic hepatitis B. World J Gastroenterol. 2007;13:2554-67. https://doi.org/10.3748/wjg.v13.i18.2554
  8. Liaw YF, Sung JJ, Chow WC, Farrell G, Lee CZ, Yuen H, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med. 2004;351:1521-31. https://doi.org/10.1056/NEJMoa033364
  9. Perrillo RP, Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology. 2001;120:1009-22. https://doi.org/10.1053/gast.2001.22461
  10. Missale G. Comparative pathogenesis of HBV and HCV. Virus Res. 2002;82:19-23. https://doi.org/10.1016/S0168-1702(01)00382-3
  11. Rapicetta MC, Ferrari M Levrero. Viral determinants and host immune responses in the pathogenesis of HBV infection. J Med Virol. 2002;67: 454-7. https://doi.org/10.1002/jmv.10096
  12. Michel ML. Immunotherapy of chronic hepatitis B by anti HBV vaccine: from present to future. Vaccine. 2001;19:2395-9. https://doi.org/10.1016/S0264-410X(00)00461-8
  13. Hyams KC. Risks of chronicity following acute hepatitis B virus infection: a review. Clin Infect Dis. 1995;20:992-1000. https://doi.org/10.1093/clinids/20.4.992
  14. Colombo M. Screening for cancer in viral hepatitis. Clin Liver Dis. 2001;5:109-22. https://doi.org/10.1016/S1089-3261(05)70156-2
  15. Velazquez RF. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis. Hepatology. 2003;37:520-7. https://doi.org/10.1053/jhep.2003.50093
  16. Son CG. A Clinical Report of Adult Acute Viral Hepatitis Type A Treated with Herbal Prescription. J Korean Oriental Med 2007;28:124-30.
  17. Cho JH, Seo SH, Yoo HS, Lee YW, Choi WJ, Son CG, et al. A Clinical Report about 57 Patients with Chronic Liver Disease. J. Korean Oriental Medicine. 2000;21:111-21.
  18. Shin JW, Son JY, Oh SM, Han SH, Wang JH, Cho JH, et al. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamineinduced chronic liver injury model in rats. World J Gastroenterol. 2006;12:6142-8. https://doi.org/10.3748/wjg.v12.i38.6142
  19. Chang JS, Liu HW, Wang KC, Chen MC, Chiang LC, Hua YC, et al. Ethanol extract of Polygonum cuspidatum inhibits hepatitis B virus in a stable HBV-producing cell line. Antiviral Res. 2005;66:29-34. https://doi.org/10.1016/j.antiviral.2004.12.006
  20. Lee JE , Kim CW, Jung YJ, Rhew KY, Kim YC, Lee JH, et al. Two Cases of Injinchunggan-tang treated patients with chronic hepatitis B relapsed after lamivudine therapy. J. of Korean Internal Medicine. 2005;Spring(1):230-9.
  21. Kim SH, Seo SH, Hong SH. The study of the effects of Gagamchunggan-tang on chronic hepatitis. J. of Korean Internal Medicine. 2003; Autumn(1):185-90.