Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Seroprevalence of Toxoplasma gondii Infection and Characteristics of Seropositive Patients in General Hospitals in Daejeon, Korea

  • Shin, Dae-Whan (Department of Infection Biology, Research Institute for Medical Science, College of Medicine, Chungnam National University) ;
  • Cha, Dong-Yeub (Department of Infection Biology, Research Institute for Medical Science, College of Medicine, Chungnam National University) ;
  • Hua, Quan Juan (Department of Infection Biology, Research Institute for Medical Science, College of Medicine, Chungnam National University) ;
  • Cha, Guang-Ho (Department of Infection Biology, Research Institute for Medical Science, College of Medicine, Chungnam National University) ;
  • Lee, Young-Ha (Department of Infection Biology, Research Institute for Medical Science, College of Medicine, Chungnam National University)
  • Published : 2009.06.30
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Abstract

To figure out the epidemiological status and relevance with other diseases in toxoplasmosis, we checked serum IgG antibody titers of 1,265 patients and medical records of seropositive patients. Seropositive rates were 6.6% by latex agglutination test (LAT) and 6.7% by ELISA. No significant differences were detected between sexes and age groups. The peak seroprevalence was detected in the 40-49-year-old age group. According to clinical department, Toxoplasma-positive rates were high in patients in psychiatry, ophthalmology, health management, emergency medicine, and thoracic surgery. Major coincidental diseases in seropositive cases were malignant neoplasms, diabetes mellitus, arthritis, chronic hepatitis B, chronic renal diseases, schizophrenia, and acute lymphadenitis, in the order of frequency. In particular, some patients with chronic hepatitis B and malignant neoplasms had high antibody titers. These results revealed that the seroprevalence of toxoplasmosis in a general hospital-based study was similar to that in a community-based study, and T. gondii seropositivity may be associated with neoplasms, diabetes, and other chronic infections.

Keywords

References

  1. Ajioka JW, Soldati D. Toxoplasma-Molecular and Cellular Biology. Norfolk, UK. Horizon Bioscience. 2007, p 37-58
  2. Torrey EF, Yolken RH. Editors' introduction: Schizophrenia and toxoplasmosis. Schizophrenia Bull 2007; 33: 727-728 https://doi.org/10.1093/schbul/sbm026
  3. Yuan Z, Gao S, Liu Q, Xia X, Liu X, Liu B, Hu R. Toxoplasma gondii antibodies in cancer patients. Cancer Lett 2007; 254: 71-74 https://doi.org/10.1016/j.canlet.2007.02.011
  4. Chai JY, Lin A, Shin EH, Oh MD, Han ET, Nam HW, Lee SH. Laboratory passage and characterization of an isolate of Toxoplasma gondii from an ocular patient in Korea. Korean J Parasitol 2003; 41: 147-154 https://doi.org/10.3347/kjp.2003.41.3.147
  5. Choi WY, Nam HW, Kwak NH, Huh W, Kim YR, Kang MW, Cho SY, Dubey JP. Foodborne outbreaks of human toxoplasmosis. J Infect Dis 1997; 175: 1280-1282 https://doi.org/10.1086/593702
  6. Lee JA, Kim DH, Kim YK, Chung EH, Choi JH, Lee HJ, Chi JG, Chai JY, Lee YH. Two cases of congenital toxoplasmosis diagnosed by polymerase chain reaction. Infect Chemother 2003; 35: 45-52
  7. Kook J, Lee HJ, Kim BI, Yun CK, Guk SM, Seo M, Park YK, Hong ST, Chai JY. Toxoplasma gondii antibody titers in sera of children admitted to the Seoul National University Children' Hospital. Korean J Parasitol 1999; 37: 27-32 https://doi.org/10.3347/kjp.1999.37.1.27
  8. Lee YH, Noh HJ, Hwang OS, Lee SK, Shin DW. Seroepidemiological study of Toxoplasma gondii infection in the rural area Okcheongun, Korea. Korean J Parasitol 2000; 38: 251-256 https://doi.org/10.3347/kjp.2000.38.4.251
  9. Song KJ, Shin JC, Shin HJ, Nam HW. Seroprevalence of toxoplasmosis in Korean pregnant women. Korean J Parasitol 2005; 43: 69-71 https://doi.org/10.3347/kjp.2005.43.2.69
  10. Yang HJ, Jin KN, Park YK, Hong SC, Bae JM, Lee SH, Choi HS, Hwang HS, Chung YB, Lee NS, Nam HW. Seroprevalence of toxoplasmosis in the residents of Cheju island, Korea. Korean J Parasitol 2000; 38: 91-93 https://doi.org/10.3347/kjp.2000.38.2.91
  11. Han K, Shin DW, Lee TY, Lee YH. Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of pregnant women in Korea. J Parasitol 2008; 94: 963-965 https://doi.org/10.1645/GE-1435.1
  12. Choi WY, Nam HW, Youn JH, Kim DJ, Komg Y, Kang SY, Cho SY. Dectection of antibodies in serum and cerebrospinal fluid to Toxoplasma gondii by indirect latex aggluination test and enzymelinked immunosorbent assay. Korean J Parasitol 1992; 30: 83-90 https://doi.org/10.3347/kjp.1992.30.2.83
  13. Choi WY, Nam HW, Youn JH, Kim WS, Kim WK. Toxoplasma antibody titers by indirect latex agglutination test in patients of Kangnam St. Mary's Hospital and Cheju Medical Center. Korean J Parasitol 1989; 27: 171-175 https://doi.org/10.3347/kjp.1989.27.3.171
  14. Spalding SM, Amendoeira MR, Klein CH, Ribeiro LC. Serological screening and toxoplasmosis exposure factors among pregnant women in south of Brazil. Rev Soc Bras Med Trop 2005; 38: 173-177 https://doi.org/10.1590/S0037-86822005000200009
  15. Shaapan RM, El-Nawawi FA, Tawfik MA. Sensitivity and specificity of various serological tests for the detection of Toxoplasma gondii infection in naturally infected sheep. Vet Parasitol 2008; 153: 359-362 https://doi.org/10.1016/j.vetpar.2008.02.016
  16. Evans R, Ashburn D, Chatterton J, Joss A, Ho-Yen D. How to detect current toxoplasma infection. Br J Biomed Sci 2002; 59: 4-6 https://doi.org/10.1080/09674845.2002.11783625
  17. Mazumder P, Chuang HY, Wentz MW, Wiedbrauk DL. Latex agglutination test for detection of antibodies to Toxoplasma gondii. J Clin Microbiol 1988; 26: 2444-2446
  18. Rigsby P, Rijpkema S, Guy EC, Francis J, Das RG. Evaluation of a candidate international standard preparation for human anti-Toxoplasma immunoglobulin G. J Clin Microbiol 2004; 42: 5133-5138 https://doi.org/10.1128/JCM.42.11.5133-5138.2004

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  25. Prevalence and Risk Factors for Toxoplasmosis in Middle Java, Indonesia vol.14, pp.1, 2009, https://doi.org/10.1007/s10393-016-1198-5
  26. Seroepidemiology of Toxoplasma gondii infection in pregnant women in west Iran: determined by ELISA and PCR analysis vol.41, pp.1, 2009, https://doi.org/10.1007/s12639-016-0784-3
  27. Serologic evidence of Toxoplasma gondii infection among cancer patients. A prospective study from Qassim region, Saudi Arabia vol.38, pp.3, 2009, https://doi.org/10.15537/smj.2017.3.18535
  28. Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis vol.111, pp.1, 2017, https://doi.org/10.1080/20477724.2016.1273597
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