Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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New Alkoxyglycerols from the Jellyfish Nemopilema nomurai

  • Liu, Ju-An (College of Pharmacy, Pusan National University) ;
  • Li, Fa-Mei (Shenyang Pharmaceutical University) ;
  • Hong, Jong-Ki (College of Pharmacy, Kyoung Hee University) ;
  • Kim, Eun-La (College of Pharmacy, Pusan National University) ;
  • Yoo, Eun-Sook (College of Medicine, Cheju National University) ;
  • Kim, Eui-Kyung (College of Veterinary Medicine, Gyeongsang National University) ;
  • Yoon, Won-Duk (National Fisheries Research & Development Institute) ;
  • Jung, Jee-H. (College of Pharmacy, Pusan National University)
  • Published : 2009.06.30
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Abstract

The great economic and social damage caused by unusual explosion of jellyfish population has attracted the attention of researchers. A chemical study on the bioactive components of the giant jellyfish Nemopilema nomurai led to the isolation of two new (1 and 2) and three known alkoxyglycerols (3 - 5), along with known monoglycerides (6 - 7) and fatty acids. Based on NMR and MS data, the structures of compounds 1 and 2 were elucidated as 1-O-[(Z)-tetradec-3-enyl]-sn-glycerol and 1-O-[(Z)-octadec-10-enyl]-sn-glycerol, respectively. The absolute configurations of compounds 1 - 7 were determined by comparison of specific optical rotation values with those reported. The isolated compounds were evaluated for suppressive effect on the proinflammatory mediators (NO, IL-6, and TNF-${\alpha}$) in murine macrophage cells. However, they were found inactive upto the concentration of 100 ${\mu}M$.

Keywords

References

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