Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Gastric Ulcer Healing Effects of Dioscorea japonica, Halloysite and Ostrea gigas Mixtures

  • Park, Jeong-Sook (College of Pharmacy, Chungbuk National University) ;
  • Han, Kun (College of Pharmacy, Chungbuk National University)
  • Published : 2009.06.30
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Abstract

A novel gastric ulcer healing formulation, a mixture of Dioscoreae Rhizoma, Halloysitum Rubrum and Ostreae Testa (Dihaos), was examined for gastric ulcer healing effects. The effect of Dihaos was assessed in various gastric ulcer models in rats. Oral administration of Dihaos significantly reduced HCl-ethanol-induced gastric ulcers. Dihaos also significantly reduced gastric and duodenal ulcers induced by cysteamine. Ostreae Testa decreased secretion of gastric juice and increased the pH of gastric juice. Furthermore, the extracts of Dioscoreae Rhizoma affected the cell proliferation of MKN 74 cells. These results suggest that the healing effect of Dihaos on gastrohemorrhagic lesions results from its protective effect against acid secretion and proliferation of mucosal cells in induced gastric ulcers in rats.

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References

  1. Debnath, P.K., Gode, K.D., Das, G.D., and Sanyal, A.K., Effect of propranolol on gastric secretion in albino rats. Br. J. Pharmacol., 51, 213-216 (1974)
  2. Goel, R.K. and Bhattacharya, S.K., Gastroduodenal mucosal defense and mucosal protective agents. Indian J. Exp. Biol., 29, 701-714 (1991)
  3. Kee, C.H., The pharmacology of Chinese Herbs, CRC Press, London, 1993
  4. Khan, H.A., Computer-assisted visualization and quantitation of experimental gastric lesions in rats. J. Pharmacol. Toxicol. Methods, 49, 89-95 (2004) https://doi.org/10.1016/j.vascn.2003.10.004
  5. Lee, R.K., Yun, H.I., Park, S.C., Park, J.I., and Cho, M.H., Effects of heattreated alumen, Halloysitum Rubrum and os sepiae in experimentally induced stomach ulcer in rats. The Journal of Applied Pharmacology, 5, 246-252 (1997)
  6. Mizui, T. and Doteuchi, M., Effect of polyamines on acidified ethanolinduced gastric lesions in rats. Jap. J. Pharmacol., 33, 939-945 (1983) https://doi.org/10.1254/jjp.33.939
  7. Sagara, K., Suto, K., Kawaura, M., and Yoshida, T., Analysis of Dioscorea Rhizoma. Pharmaceutical Technology Japan, 4, 811-813 (1988)
  8. Selye, H. and Szabo, S., Experimental model for production of perforating duodenal ulcers by cysteamine in the rat. Nature, 244, 458- 459 (1973) https://doi.org/10.1038/244458a0
  9. Shay, H., Sun, D.C.H., and Gruenstein, M., A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology, 26, 906-913 (1954)
  10. Tarnawski, A., Cellular and molecular mechanisms of ulcer healing. Drugs Today, 33, 697-706 (1997)
  11. Wu, J.N., Chinese Materia Medica, Oxford University Press, New York, 2005