Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Preventive and Inhibitory Effect of Korean Red Ginseng on Collagen-Induced Arthritis in Mice

고려홍삼의 콜라겐 유도 관절염의 예방과 억제효과

  • Cha, Mi-Ran (Laboratory for Leukocyte Signaling Research, BK21 Program, and Department of Pharmacology and 1Oxicology, Inha University School of Medicine) ;
  • Wang, Yutie (Laboratory for Leukocyte Signaling Research, BK21 Program, and Department of Pharmacology and 1Oxicology, Inha University School of Medicine) ;
  • Jang, Jin-Sun (Laboratory for Leukocyte Signaling Research, BK21 Program, and Department of Pharmacology and 1Oxicology, Inha University School of Medicine) ;
  • Kim, Chae-Kyun (Laboratory for Leukocyte Signaling Research, BK21 Program, and Department of Pharmacology and 1Oxicology, Inha University School of Medicine)
  • 조미란 (인하대학교 의과대학 약리학교실) ;
  • 왕옥철 (인하대학교 의과대학 약리학교실) ;
  • 장진선 (인하대학교 의과대학 약리학교실) ;
  • 김채균 (인하대학교 의과대학 약리학교실)
  • Published : 2009.06.30
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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by inhibiting the secretion of inflammatory cytokines like $TNF-{\alpha}$, IL-1, -6, and -8, and $IPN-{\gamma}$. In this study, whether KRG extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To induce arthritis, type II collagen emulsified in Complete Freund's Adjuvant was intradermally injected into the base of the tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund's Adjuvant was administered. The oral administration of KRG extract for 8${\sim}$10 weeks at the dose of 300 mg/kg (three days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-${\alpha}$, but the plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that KRG has preventive and inhibitory effects on collagen-induced arthritis.

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