Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

The Experimental Study on Anti-inflammation and Anti-oxidation of GaeYongHwan

개용환(改容丸)의 항염 및 항산화 효과에 대한 실험적 연구

  • Seo, Hyeong-Sik (Department of Ophthalmology, Otolaryngology and Dermatology, Oriental Medicine Hospital, Sangju University)
  • Published : 2009.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : This study was performed to investigate the anti-inflammatory and anti-oxidantic effects of GaeYongHwan(GYH) extract which has been used for patients with acnes. Methods : Anti-inflammatory and anti-oxidantic effects of GYH extract were tested in terms of inhibitory ability of Nitric oxide(NO) production, 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging activity and anti-bacterial effects against Propionibacterium acnes(P. acnes). Results : 1. All GYH treated groups did not show cytotoxicity. 2. Treatment with $100{\mu}g/m{\ell}$ of GYH extract lowered production levels of NO significantly compared to non-treated control or normal. 3. All of GYH treated groups did not show DPPH free radical scavenging activities. 4. All of GYH treated groups did not show anti-baterial action against P. acnes. Conclusions : These results imply that GYH extract has anti-inflammatory effect to treat acnes.

Keywords

References

  1. Gang YH. Atlas of Skin Disease. Seoul. Hanmibook. 2006:205-73
  2. Jeong JY, Han GH. Common Skin Disease in Korea. Seoul. MDworld. 2009:13,443
  3. Sohn HY, Kim YS, Kum EJ, Kwon YS, Son KH. Screening of anti-acne activity of natural products against Propionibacterium acnes. Kor. J. Microbiol. Biotechnol. 2006;34(3):265-72
  4. Min HY, Park EJ, Lee SK, Cho YJ. Effects of grape extracts on free radical scavenging activity and inhibition of pro-inflammatory mediator production in mouse macrophage cells. Korean J. Food Sci. Technol. 2003;35(1):132-7
  5. Jeong GP. UiHakSimO. Seoul. JeongDam. 2002:661-2
  6. Kim NK, Jung JH, Choi SW, Yoon CS, Studies on the antioxidative effect of the BuckWheat (Fagopyrum esculentum Moench) extract and its Protective Role against Cadmium-mediated stress, J. Soc. Cosmet. Scientists Korea, 2005;31(2):197-206
  7. Kim H, Lim H, Kim B, Kim H, Choi S, Yoon C. Studies on the anti-acne effect of Agrimonia pilosa Ledeb, J. Soc. Cosmet. Scientists Korea, 2006;32(1):53-8
  8. Lee S. Antimicrobial effect of Bamboo(Phyllosrachys Bambusoides) Essential Oil on Trichophyton and Pityrosporum, J. Fd Hyg. Safety, 2003;18(3):113-7
  9. T. Mosmann, Rapid colorimetric assay for cellular growth and survival application of proliferation and cytotoxicity, J. Immunol. Methods, 1983;65:55 https://doi.org/10.1016/0022-1759(83)90303-4
  10. Han SM, Lee KG, Yeao JH, Kweon HY, Park KK. Anti-inflammatory effect of the venom from asian honeybees(Apis cerana L.) on inducible nitric oxide synthase and tumor necrosis factor-$\alpha$ in Raw 264.7 cell line, Korean J. Apiculture, 2004;19:89
  11. M. S. Blois, Antioxidant determinanations by the use of a stable free radical, Nature, 1958;181:1199 https://doi.org/10.1038/1811199a0
  12. Lee SE, Son DW, Yoon YP, Lim TY, Kim HS. Screening of Traditional Herbral Medicines to Develop New Materials for Anti-aging and Anti-wrinkle in the skin, J. Soc. Cosmet. Scientists Korea, 2005;31(2):147-52
  13. Ahn SK, Jang GH, Song JH, Cheon SH. Common Skin Disease. Seoul. Doctor's Book. 2009;115-45,988
  14. Kim MA, Kim MB, Shin SH, Byun SM, Ko WS, Lee HS, Park SG, Yoon HJ. The study on external treatment of oriental medical care on acne. J. Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology. 2008;21(2):102-11
  15. Yukie Niwa. If auto-oxidative be controled, human life will be long without disease. Seoul. Moonye. 2001:140-1, 152-4

Cited by

  1. Review on the Acne Related Articles Published in Korean Medical Journals - Focusing on Experimental Studies Published after 2005 - vol.28, pp.1, 2015, https://doi.org/10.15204/jkobgy.2015.28.1.113