Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Inhibitory Effects of Peonia japonica Water Extract on Skin Aging (II) - Focussed on Inhibitory Effects of Wrinkle Formation-

백작약 열수추출물의 피부노화 억제 효과 (II) -주름형성 억제 효과를 중심으로-

  • Kwon, Mi-Hwa (Department of Toxicolopathology, National Institute of Toxicological Research) ;
  • Choi, So-Young (Department of Public Health, Keimyung University) ;
  • Kim, Young-Chul (Department of Public Health, Keimyung University)
  • 권미화 (국립독성과학원 독성병리과) ;
  • 최소영 (계명대학교 대학원 공중보건학과) ;
  • 김영철 (계명대학교 대학원 공중보건학과)
  • Published : 2009.06.30
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Abstract

To investigate the inhibitory effects of Peonia japonica water extract(PJWE) on skin wrinkle formation, skin wrinkles were induced by both the irradiation of UVB and the application of squalene monohydroperoxide to the backs of hairless mice for 4 weeks. And at the same time experimental materials were applied topically. Wrinkles for the control (C) group were formed as a pattern of deep furrows and thick crests. Whereas wrinkles for the positive control (PC, 0.01% retinoic acid) and experimental(E, PJWE) groups were formed as a pattern of shallow furrows and thin crests, which were similar to that of the normal(N) group. Collagen and elastic fibers in dermis of the PC and E groups were almost intact with a regular arrangement, which were similar to those of the N group. The activity of xanthine oxidase, the free radical generating enzyme, was significantly lower in the E group than the C and PC groups. The activities of superoxide dismutase and catalase, the free radical scavenging enzymes, were much higher in the E group than the C and PC groups and similar to the N group. As for the amount of matrix metalloproteinase-3(MMP-3) expression, PC and E groups were significantly lower than the C group. Therefore, PJWE could be very effective natural herbal material for the inhibition or improvement of wrinkle formation in hairless mice skin.

Keywords

References

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