Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Rumecis Radix Water Extract on Development of Atopic Dermatitis in BALB/c Mice

Balb/c 마우스의 아토피피부염에 대한 참소리쟁이 물추출물의 효과

  • Ahn, Ji-Young (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Im, Lee-Rang (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Kim, Jun-Ho (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute) ;
  • Park, Jae-Hoon (Oracle Dermatology Clinic) ;
  • Kim, Dae-Ki (Department of Immunology, Medical School, Chonbuk National University) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
  • 안지영 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 임이랑 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 김준호 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 박재훈 (오라클피부과) ;
  • 김대기 (전북대학교 의과대학) ;
  • 이영미 (원광대학교 약학대학 한약학과 및 원광한약연구소)
  • Published : 2009.09.30
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Abstract

The roots of Rumecis Radix have been used for the treatment of heat phlegm, jaundice, constipation, scabies and uterine hemorrhage. The aim of this study was to confirm whether Rumecis Radix water extract (RJWE) has a preventive effect on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-applied BALB/c mice. Oral administration (12.5 mg/kg, 25 mg/kg) and topical application (0.5 mg/mouse, 1.0 mg/mouse) of RJWE decreased the development of AD-like skin lesions, ear swelling, spleen weight and total serum IgE. RJWE significantly also inhibited the infiltration of mast cells in the dorsal skin. Furthermore, the release of histamine from rat peritoneal mast cells (RPMCs) was suppressed significantly. These results suggest that the inhibitory effect of RJWE on AD might be associated with mast cells.

Keywords

References

  1. Leung, D. Y. M. (2000) Atopic dermatitis: new insights and opportunities for therapeutic intervention. J. Allergy Clin. Immunol. 105: 860-876 https://doi.org/10.1067/mai.2000.106484
  2. Arellano, F. M., Wentworth, C. E. and Arana, A. (2007) Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis. J. Invest. Dermatol. 127: 808-816 https://doi.org/10.1038/sj.jid.5700622
  3. Furue, M., Terao, H., Moroi, Y., Koga, T., Kubota, Y., Nakayama, J., Furukawa, F., Tanaka, Y., Katayama, I., Kinukawa, N., Nose, Y. and Urabe, K. (2004) Dosage and adverse effects of topical tacrolimus and steroids in daily management of atopic dermatitis. J. Dermatol. 31: 277-283 https://doi.org/10.1111/j.1346-8138.2004.tb00673.x
  4. Koo, J. and Arain, S. (1998) Traditional Chinese medicine for the treatment of dermatologic disorders. Arch. Dermatol. 134: 1388-1393 https://doi.org/10.1001/archderm.134.11.1388
  5. Gao, X. K., Fuseda, K., Shibata, T., Tanaka, H., Inagaki, N. and Nagai, H. (2005) Kampo medicines for mite antigeninduced allergic dermatitis in NC/Nga mice. Evid. Based. Complement. alternat. Med. 2: 191-199 https://doi.org/10.1093/ecam/neh077
  6. 전국한의과대학 본초학교수 공편저 (1998) 본초학. 398. 영림사, 서울
  7. Bae, K. (2000) Medicinal Plants of Korea. 92. Kyo-Hak Publishing Co., Seoul
  8. Li, Y. P., Takamiyagi, A., Ramzi, S. T. and Nonaka, S. (2000) Inhibitory effect of Rumex Japonicus Houtt on the porphyrin photooxidative reaction. J. Dermatol. 27: 761-768 https://doi.org/10.1111/j.1346-8138.2000.tb02278.x
  9. Park, Y. K. (2003) Studies on the Anti-oxidative effects of Rumexis Radix. Kor. J. Herbology 18: 269-277
  10. Yildirim, A., Mavi, A. and Kara, A. A. (2001) Determination of antioxidant and antimicrobial activities of Rumex crispus L. extracts. J. Agric. Food Chem. 49:4083-4989 https://doi.org/10.1021/jf0103572
  11. Cho, K. H. and Kim, H. S. (1980) A Study of Antifungal Activity with Rumex japonicus Huttuyn. Kor. J. Dermatology 18: 383-389
  12. Lee, H. S., Kim, S. K., Han, J. B., Choi, H. M., Park, J. H., Kim, E. C., Choi, M. S., An, H. J., Um, J. Y., Kim, H. M. and Min, B. I. (2006) Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Br. J. Dermatol. 155: 33-38 https://doi.org/10.1111/j.1365-2133.2006.07303.x
  13. Kotani, M., Matsumoto, M., Fujita, A., Higa, S., Wang, W., Suemura, M., Kishimoto, T. and Tanaka T. (2000) Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. allergy Clin. Immunol. 106: 159-166 https://doi.org/10.1067/mai.2000.107194