Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Hepatoprotective Activities of Rubus coreanus Depends on the Degree of Ripening

  • Lee, Young-Ik (Liver Cell Signal Transduction Lab., Industrial Bioresource Research Center) ;
  • Choi, Seoung-Ku (Liver Cell Signal Transduction Lab., Industrial Bioresource Research Center) ;
  • Yang, Ji-Young (Department of Gastroenterology, Wonkwang University, School of Medicine and Hospital) ;
  • Cho, Jin-Sook (Lee's Biotech Co., BVC#203, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Tae-Hyeon (Department of Gastroenterology, Wonkwang University, School of Medicine and Hospital)
  • Published : 2009.09.30
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Abstract

Rubus coreanus, commonly known as 'red raspberry' is used as a traditional oriental medicine in Korea for the management of diseases such as impotence, spermatorrhea and athsma, and for allergies, in combination with other herbal preparations, in many centuries. We undertook a comparison of the hepatoprotective effect of ethanol extracts of the unripe (UREx) and ripe (RREx) R. coreanus extract against acetaminophen (AAP) induced hepatotoxicity in rats. UREx reduced the elevated alanine aminotransferase (ALP), aspartate aminotransferase (AST), total bilirubin (TB), alkaline phosphatase (AP), lipid peroxide and nitric oxide content which had been increased by AAP administration. UREx also increased the cellular glutathione (GSH) content and induced the glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) content which had been decreased by AAP. RREx did not exhibit strong hepatoprotective effect or antioxidant activity under the same conditions. The experimental results show that the degree of the ripening of R. coreanus affects the hepatoprotective activity in the AAP-intoxicated rats. These findings of a protective mechanism are supportive evidence for the utility of unripened R. coreanus in traditional medicine for liver ailments.

Keywords

References

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