Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of Korean Red Ginseng on Somatic Symptoms in a General Population in Korea

일반인에서 홍삼이 신체증상에 미치는 효과

  • Kang, Eun-Ho (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Woo-Yong (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Song, Yoon-Jae (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yu, Bum-Hee (Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 강은호 (성균관대학교 의과대학 삼성서울병원 정신과) ;
  • 신우용 (성균관대학교 의과대학 삼성서울병원 정신과) ;
  • 송윤재 (성균관대학교 의과대학 삼성서울병원 정신과) ;
  • 유범희 (성균관대학교 의과대학 삼성서울병원 정신과)
  • Published : 2009.09.30
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Abstract

Various somatic symptoms are known to be related to stress in a general population. Korean red ginseng has been used as a therapeutic agent for the treatment and prevention of many diseases in Oriental medicine. There exist no data, however, on the effect of Korean red ginseng on somatic symptoms in a general population. In this study, 21 normal subjects were randomly assigned to the Korean-red-ginseng group, and 18 subjects to the placebo group. The subjects took 3 g Korean red ginseng or placebo every day for three weeks. After the three-week treatment, there was a

본 연구는 신체 증상을 호소하는 정상인들을 대상으로 3주간 홍삼 또는 위약을 투여하였고, 홍삼 복용군에서 위약 복용군에 비해 신체 증상 감소 정도가 더 큼을 보여주었다.

Keywords

References

  1. Kalia M. Assessing the economic impact of stress--the modern day hidden epidemic. Metabolism 51: 49-53 (2002) https://doi.org/10.1053/meta.2002.33193
  2. Chrousos GP. Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann N Y Acad Sci. 851: 311-35 (1998) https://doi.org/10.1111/j.1749-6632.1998.tb09006.x
  3. Yamamoto S, Loerbroks A, Terris DD. Measuring the effect of workplace health promotion interventions on 'presenteeism':a potential role for biomarkers. Prev Med. 48: 471-472 (2009) https://doi.org/10.1016/j.ypmed.2009.02.019
  4. Korte SM, Koolhaas JM, Wingfield JC, McEwen BS. The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neurosci Biobehav Rev. 29: 3-38 (2005) https://doi.org/10.1016/j.neubiorev.2004.08.009
  5. McEwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci. 840: 33-44 (1998) https://doi.org/10.1111/j.1749-6632.1998.tb09546.x
  6. McEwen BS. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 22:108-124 (2000) https://doi.org/10.1016/S0893-133X(99)00129-3
  7. Figueredo VM. The time has come for physicians to take notice: the impact of psychosocial stressors on the heart. Am J Med. 122: 704-12 (2009) https://doi.org/10.1016/j.amjmed.2009.05.001
  8. Ferrara M, Langiano E, Di Brango T, De Vito E, Di Cioccio L, Bauco C. Prevalence of stress, anxiety and depression in with Alzheimer caregivers. Health Qual Life Outcomes 6:93 (2008) https://doi.org/10.1186/1477-7525-6-93
  9. Peterson U, Demerouti E, Bergstrom G, Samuelsson M, Asberg M, Nygren A. Burnout and physical and mental health among Swedish healthcare workers. J Adv Nurs. 62:84-95 (2008) https://doi.org/10.1111/j.1365-2648.2007.04580.x
  10. Godin I, Kittel F. Differential economic stability and psychosocial stress at work: associations with psychosomatic complaints and absenteeism. Soc Sci Med. 58: 1543-1553 (2004) https://doi.org/10.1016/S0277-9536(03)00345-9
  11. Lee SH, Jung BH, Kim SY, Lee EH, Chung BC. The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress. Pharmacol Res. 54: 46-49 (2006) https://doi.org/10.1016/j.phrs.2006.02.001
  12. Shin HY, Jeong HJ, Hong SH, Um JY, Shin TY, Kwon SJ, Jee SY, Seo BI, Shin SS, Yang DC, Kim HM. The effect of Panax ginseng on forced immobility time & immune function in mice. Indian J Med Res. 124: 199-206 (2006)
  13. Jiang QS, Huang XN, Dai ZK, Yang GZ, Zhou QX, Shi JS, Wu Q. Inhibitory effect of ginsenoside Rb1 on cardiac hypertrophy induced by monocrotaline in rat. J Ethnopharmacol. 111: 567-572 (2007) https://doi.org/10.1016/j.jep.2007.01.006
  14. Kim DH, Moon YS, Jung JS, Min SK, Son BK, Suh HW, Song DK. Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neurosci Lett. 343: 62-66 (2003) https://doi.org/10.1016/S0304-3940(03)00300-8
  15. Derogatis LR. Symptom Checklist-90-Revised (SCL-90-R) manual I. Clinical Psychometric Research Unit, Johns Hopkins University, Baltimore (1977)
  16. Stewart JA. The detrimental effects of allostasis: allostatic load as a measure of cumulative stress. J Physiol Anthropol. 25: 133-145 (2006) https://doi.org/10.2114/jpa2.25.133
  17. Jessop DS, Turner-Cobb JM. Measurement and meaning of salivary cortisol: a focus on health and disease in children. Stress 11: 1-14 (2008) https://doi.org/10.1080/10253890701365527
  18. Butler GC, Yamamoto Y, Hughson RL. Heart rate variability to monitor autonomic nervous system activity during orthostatic stress. J Clin Pharmacol. 34: 558-562 (1994) https://doi.org/10.1002/j.1552-4604.1994.tb02007.x
  19. Gunnar MR, Talge NM, Herrera A. Stressor paradigms in developmental studies: what does and does not work to produce mean increases in salivary cortisol. Psychoneuroendocrinol. 34: 953-967 (2009) https://doi.org/10.1016/j.psyneuen.2009.02.010
  20. Kaneko H, Nakanishi K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease. J Pharmacol Sci. 95: 158-162 (2004) https://doi.org/10.1254/jphs.FMJ04001X5
  21. Tachikawa E, Kudo K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: suppression of adrenal medullary function in vitro by ginseng. J Pharmacol Sci. 95: 140-144 (2004) https://doi.org/10.1254/jphs.FMJ04001X2
  22. Predy GN, Goel V, Lovlin R, Donner A, Stitt L, Basu TK. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ. 173: 1043-1048 (2005) https://doi.org/10.1503/cmaj.1041470
  23. Koh KB. Evaluation and treatment of somatization. In: Stress and psychosomatic medicine 231-249. Ilzogak, Seoul (2002)

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