Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of Warm Needling on the Acute Knee Arthritis Induced by Carrageenan in Rats

흰쥐에서 carrageenan 유발 급성(急性) 슬관절염(膝關節炎)에 대한 혈위별(穴位別) 온침자극(溫鍼刺戟)의 효과(效果)

  • Jang, Jae-Young (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Kwon, Oh-Sang (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Kim, Young-Sun (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Kim, Jae-Hyo (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Kim, Yu-Ri (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Ahn, Seoung-Hoon (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Sohn, In-Chul (Dept. of Meridian & Acupoint, College of Korean Medicine, Wonkwang University)
  • 장재영 (원광대학교 한의과대학 경락경혈학교실) ;
  • 권오상 (원광대학교 한의과대학 경락경혈학교실) ;
  • 김영선 (원광대학교 한의과대학 경락경혈학교실) ;
  • 김재효 (원광대학교 한의과대학 경락경혈학교실) ;
  • 김유리 (원광대학교 한의과대학 경락경혈학교실) ;
  • 안성훈 (원광대학교 한의과대학 경락경혈학교실) ;
  • 손인철 (원광대학교 한의과대학 경락경혈학교실)
  • Published : 2009.06.27
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Abstract

Objectives: Warm needling combines simultaneously the effects of acupuncture and moxibustion. This study was to investigate whether warm needling could relieve acute knee arthritis induced by carrageenan in rats. Methods: To illuminate the underlying mechanisms of the warm needling-induced antinociception, weight bearing force (WBF) was observed on the acute knee arthritic rat model. Under general anesthesia, ST36, SP9, Hakjung extra point, LI4 were punctured and stimulated with 30 mg moxa ball combustion on top of the needle (${\emptyset}0.18{\times}8mm$). Results: In behavioral test, rats subsequently showed a reduced stepping force of the affected limb 3 hours after the induction of arthritis. Warm needling on the contralateral or ipsilateral ST36 failed to show antinociceptive effect on the acute knee arthritis. Warm needling on the contralateral SP9 or LI4 increased WBF values to normal level in the acute stage of the arthritis. Warm needling on the Hakjung extra-point resulted in the significant antinociceptive effects through acute stage. These effects of warm needling were suppressed by opioids receptor antagonist naltrexone (10 mg/kg, i.p.) and alpha adrenoceptor antagonist phentolamine (5 mg/kg, i.p.). Conclusion: The data suggest that warm needling-induced antinociception is differently mediated by acupoints and accomplished by activating the descending inhibitory systems including endogenous opioids and $\alpha$-adrenoceptors.

Keywords

References

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