Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Effects of gamgook(Chrysanthemum indicum L.) herbal-acupuncture on lipid lowering effect, anti-oxidative capacity and anti-inflammatory effect in rat fed high oxidized fat

감국약침이 과산화지질을 급여한 흰쥐의 지질대사, 항산화 및 면역계에 미치는 영향

  • Lim, Yun-Taek (Dept. of Meridian & Acupoint, College of Oriental Medicine, Sangji University) ;
  • Lee, Hyang-Sook (Dept. of Meridian & Acupoint, College of Oriental Medicine, Sangji University) ;
  • Lee, Joon-Moo (Dept. of Meridian & Acupoint, College of Oriental Medicine, Sangji University) ;
  • Lee, Eun (Dept. of Pharmaceutical Engineering, College of Health Sciences, Sangji University)
  • 임윤택 (상지대학교 한의학과 경락경혈학교실) ;
  • 이향숙 (상지대학교 한의학과 경락경혈학교실) ;
  • 이준무 (상지대학교 한의학과 경락경혈학교실) ;
  • 이은 (상지대학교 보건과학대학 제약공학과)
  • Published : 2009.06.27
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Abstract

Objectives: To investigate the effects of Chrysanthemum indicum L. pharmacopuncture on lipids, antioxidant capacity and anti-inflammation in rats fed high-fat diet. Methods: Hyperlipidemic rats induced by high-fat diet were divided into 5 groups: no treatment control (normal, n=8), high-fat diet only control (control, n=8), high-fat diet and Chrysanthemum indicum L. pharmacopuncture at CV4 group (TI, n=8), high-fat diet and Chrysanthemum indicum L. pharmacopuncture at CV17 group (TII, n=8), and high-fat diet and Chrysanthemum indicum L. pharmacopuncture at EX-HN3 group (TIII, n=8). They were given pharmacopuncture accordingly every other day for two weeks followed by analyses of lowering lipids effects, oxidative capacity and anti-inflammatory effects. Results: Compared with the control, pharmacopuncture groups showed significantly decreased plasma total cholesterol (TC), liver thiobarbituric acid reactive substance (TBARS), catalase, glutathione peroxidase, neutrophils, monocytes, plasma and liver IL-$1{\beta}$, and plasma and liver IL-6. In other parameters including plasma and liver triglyceride, liver TC, LDL-cholesterol, HDL-cholesterol, liver TBARS, supraoxide dismutase, total protein, albumin, blood cell analysis, plasma and liver TNF-$\alpha$, and IL-10, there was no significant difference between control and pharmacopuncture groups. No clear acupoint-specificity was observed. Conclusions: Chrysanthemum indicum L. pharmacopuncture may improve control of hyperlipidemia.

Keywords

References

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