Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats

음곡 차전자 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

  • Park, Byong-Mun (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Hur, Boo (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Yim, Yun-Kyoung (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University)
  • 박병문 (대전대학교 한의과대학 경락경혈학교실) ;
  • 허부 (대전대학교 한의과대학 경락경혈학교실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Published : 2009.06.27
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : This study aimed to evaluate the effects of Plantaginis Semen herbal-acupuncture (PS-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rat. Methods : The authors performed several experimental items including measurements of urinary volume, WBC in blood, BUN, creatine, TNF-$\alpha$, CINC-1 in serum, creatinine, total protein in urine, TNF-$\alpha$, MPO in kidney and histological analysis of renal tissue. Results : PS-HA at KI10 significantly reduced WBC in blood, BUN, TNF-$\alpha$ in serum of LPS-stimulated rats. PS-HA at KI10 significantly increased urinary volume in LPS-stimulated rats. And PS-HA at KI10 significantly reduced MPO in kidney of LPS-stimulated rats. Conclusion : Taken together, PS-HA at KI10 has a therapeutic effect on nephritis in LPS-stimulated rat. Therefore, it is suggested that PS-HA at KI10 may be an useful therapeutics for nephritis in clinical field.

Keywords

References

  1. 杜鎬京. 동의신계학. 서울 : 동양과학연구회. 1993 : 226, 228, 247, 238-47, 326, 334-6.
  2. J. CLAUDE bennett, FRED PLUM. Cecil textbook of medicine. 20th. philadelphia : saunders. 1996 : 552, 575-7.
  3. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signal activation of adaptive immunity. Nature. 1997 ; 388(6640) : 394-7. https://doi.org/10.1038/41131
  4. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. 2000 ; 406(6797) : 782-7. https://doi.org/10.1038/35021228
  5. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. Toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J immunol. 1999 ; 162(7) : 3749-52.
  6. 임윤경, 김준표, 김태한. 대학경락경혈학각론. 대전 : 오비기획. 2006 : 676-8.
  7. 康秉秀, 高雲彩, 金圭烈, 金先熙, 盧昇鉉, 朴涌基 외. 本草學. 서울 : 永林社. 2004 : 357-8.
  8. 최정배, 이경환, 김용성. 육미지황탕가황기인삼 추출물의 Cisplatin 유도 신장독성 보호효과. 대한한방내과학회지. 2003 ; 24(3) : 579-87.
  9. 황영근, 정지천. 수은으로 유발된 토끼의 신장 기능 손상에 대한 단삼(丹參)의 효과. 대한한방내과학회지. 2000 ; 21(2) : 227-34.
  10. 윤철호, 정지천, 신의섭. Bromobenzene으로 유도된 신장기능저하에 미치는 녹용 약침의 항산화 효과. 대한한방내과학회지. 1999 ; 20(2) : 287-302.
  11. 권선호, 송춘호. CCl$_{4}$로 투여한 백서 간손상에 미치는 차전자약침의 영향. 대한침구학회지. 2001 ; 18(4) : 152-60.
  12. 조시용, 김철홍, 윤현민, 장경전, 안창범, 송춘호. 車前子藥鍼이 急性腎不全 白鼠에 미치는 影響. 경락경혈학회지. 2005 ; 22(4) : 117-27.
  13. 박춘하, 채우석, 윤여충. 차전자 약침이 cisplatine에 의해 유발된 급성 신부전에 미치는 영향. 대한침구학회지. 2004 ; 21(2) : 155-66.
  14. Cohen JJ, Black AJ, Wertheim SJ. Direct effects of endotoxin on the function of the isolated perfused rat kidney. Kidney Int. 1990 ; 37(5) : 1219-26. https://doi.org/10.1038/ki.1990.105
  15. Trop M, Schiffrin EJ, Carter EA. Effect of acute and chronic lipopolysaccharide (LPS) administration on reticuloendothelial system (RES) phagocytic activity in vivo. Burns. 1992 ; 18(2) : 107-8. https://doi.org/10.1016/0305-4179(92)90004-E
  16. Glauser MP, Zanetti G, BaumgartnerJ-D, Cohen J. Septic shock Pathogenesis. Lancet. 1991 ; 338 : 732-6. https://doi.org/10.1016/0140-6736(91)91452-Z
  17. Ohmori Y, Hamilton TA. A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun. 1990 ; 168 : 1261-7. https://doi.org/10.1016/0006-291X(90)91164-N
  18. Tannenbaum CS, Koemer TJ, Jansen MM, Hamilton TA. Characteriation of Lipopolysaccharide-induced macrophage gene expression. J immunol. 1988 ; 140 : 3640-5.
  19. 허준. 동의보감. 경남 : 동의보감출판사. 2005 : 2151.
  20. Nakagawa, H, Komori, N, Shibata, F, Ikesue, A, Konishi, K, Fujioka, M, and Kato, H. Identification of cytokineinduced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization. Biochem. J. 1994 ; 301: 545–50.
  21. M, Taie S, Chujo K, Asaga T, Iwanaga Y, Ono J, Maekawa N. Urinary trypsin inhibitor reduces inflammatory response in kidney induced by lipopolysaccharide. Ueki J Biosci Bioeng. 2007 ; 104(4) : 315-20. https://doi.org/10.1263/jbb.104.315