Effect of Purgative Action with Natrii Sulfas on Brain Edema of MCAO Rats

망초(芒硝)의 사하작용(瀉下作用)이 MCAO 흰쥐의 뇌부종(腦浮腫)에 미치는 영향

  • Kang, Ho-Chang (Division of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim, Bum-Hoi (Department of Anatomy, College of Oriental Medicine, Dong-Eui University) ;
  • Shim, Eun-Sheb (Division of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kang, Il-Hwan (Division of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim, Seong-Joon (Division of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kang, Hee (Division of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Sohn, Nak-Won (Division of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • 강호창 (경희대학교 동서의학대학원 한의과학) ;
  • 김범회 (동의대학교 한의과대학 해부학교실) ;
  • 심은섭 (경희대학교 동서의학대학원 한의과학) ;
  • 강일환 (경희대학교 동서의학대학원 한의과학) ;
  • 김성준 (경희대학교 동서의학대학원 한의과학) ;
  • 강희 (경희대학교 동서의학대학원 한의과학) ;
  • 손낙원 (경희대학교 동서의학대학원 한의과학)
  • Published : 2009.09.30

Abstract

Objectives: This study aimed to evaluate the effect of purgation therapy with Natrii sulfas, an oriental medical therapy for stroke patients with constipation, on physiological indexes and the brain edema of rats. Methods: Brain edema was induced by the middle cerebral artery occlusion (MCAO); Natrii sulfas was administered once after the MCAO. At 3, 6, 15, 24, 48 hours after reperfusion, physiological indexes such as fecal weight, urine volume and water content in stool were assessed, and at 48 hours after reperfusion the edema index was measured. Results: 1. Purgation therapy with Natrii sulfas significantly improved the reduction of fecal weight caused by ischemic insult (P<0.05). 2. Purgation therapy with Natrii sulfas significantly improved the reduction of urine volume caused by ischemic insult (P<0.05). 3. Purgation therapy with Natrii sulfas significantly improved the reduction of water content in stool caused by ischemic insult (P<0.05). 4. Purgation therapy with Natrii sulfas did not improve the neurological symptom caused by ischemic insult. 5. Purgation therapy with Natrii sulfas did not attenuate the total infarct volume caused by ischemic insult. 6. Purgation therapy with Natrii sulfas attenuated the brain edema caused by ischemic insult (P<0.05). Conclusions: These results suggest that purgation therapy with Natrii sulfas improves some important symptoms and has a protective effect on the brain edema caused by ischemic insult.

Keywords

References

  1. 전국한의과대학 본초학교수 공저. 본초학. 서울:영림사. 1994:244-5.
  2. Hwang CW, Byun I. A Literatual study on the Emergency care and Administration method of Medical emergency. Hye Hwa Medicine. 1994;1(3):16-45.
  3. 김영석. 임상중풍학. 서울:서원당. 1997:303-48.
  4. Koo BS, Lee DS, Moon SK, Go CN, Cho KH, Bae HS, Lee KS, Kim YS. Effects of Daeseungkitang on Constipated Stroke Patients. The Journal of Korean Oriental Medicine. 2000;21(2):3-13.
  5. 申錦林, 陳評, 趙安氏, 劉日煊, 李宏云, 陽志運. 黃液直腸摘注治療急性腦出血的療效觀察. 中醫藥 硏究.1998;14(1):27-8
  6. Fisher M. Characterizing the target of acute stroke therapy. Stroke. 1997;28(4):866-72. https://doi.org/10.1161/01.STR.28.4.866
  7. 서울대학교의과대학. 신경학원론. 서울:서울대학교출판부. 1998:178-88, 339-49, 521-50.
  8. Cho KH. Medical Management of Spontaneous Intracerebral Hemorrhage. Korean Journal of Stroke. 2003:5(1):26-9.
  9. Alberts MJ. Diagnosis and treatment of ischemic stroke. Am J Med. 1999;106(2):211-21. https://doi.org/10.1016/S0002-9343(98)00414-8
  10. Lee Won Chul. Research on the Xiafa used at the acute stages of Stroke. The Jounal of Korean Oriental Medicine. 1998;19(1):385-90.
  11. Im SU. The Clinical Evaluation of Defecation in Stroke Patients. Journal of Korea Institute of Oriental Medical Informatics. 1997;3(1)7-11.
  12. Alberts MJ. Treatment of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2001;10(2 Pt 2):10-7. https://doi.org/10.1053/jscd.2001.24778
  13. 김완희. 한의학원론. 서울:성보사. 1982:398, 402-4, 506-8.
  14. Son DH, Jo GH, Kim YS, Bae HS, Lee GS, Lee YG. The Comparison Study on the Effect of Bowel Movement between Bo-Ryu Enema(Bao-Liu Enema) and General Enema in Patients at the Acute Stage of Cerebrovascular Accident. The Journal of Korean Oriental Medicine. 2001;22(3):51-62.
  15. 대한내과학회 해리슨내과학 편집위원회. 해리슨내과학. 서울:도서출판 MIP. 2003;252.
  16. Bharucha AE. Constipation. Best Pract Res Clin Gastroenterol. 2007;21(4):709-31. https://doi.org/10.1016/j.bpg.2007.07.001
  17. Ullman T, Reding M. Gastrointestinal dysfunction in stroke. Semin Neurol. 1996;16(3):269-75. https://doi.org/10.1055/s-2008-1040984
  18. Winge K, Rasmussen D, Werdelin LM. Constipation in neurological diseases. J Neurol Neurosurg Psychiatry. 2003;74(1):13-9. https://doi.org/10.1136/jnnp.74.1.13
  19. Johanson JF, Sonnenberg A, Koch TR, McCarty DJ. Association of constipation with neurologic diseases. Dig Dis Sci. 1992;37(2):179-86. https://doi.org/10.1007/BF01308169
  20. Camilleri M, Bharucha AE. Gastrointestinal dysfunction in neurologic disease. Semin Neurol. 1996;16(3):203-16. https://doi.org/10.1055/s-2008-1040977
  21. Han TR. Prognostic Evaluation in Stroke Rehabilitation. Journal of Korean Academy of Rehabilitation Medicine. 1997;21(5):817-25.
  22. Chakrabarti SD, Ganguly R, Chatterjee SK, Chakravarty A. Squatting, blood pressure and stroke. J Assoc Physicians India. 2002;50:382-6.
  23. Krogh K, Christensen P, Laurberg S. Colorectal symptoms in patients with neurological diseases. Acta Neurol Scand. 2001;103(6):335-43. https://doi.org/10.1034/j.1600-0404.2001.103006335.x
  24. Indredavik B, Bakke F, Slordahl SA, Rokseth R, Hâheim LL. Treatment in a combined acute and rehabilitation stroke unit: which aspects are most Important? Stroke. 1999;30(5):917-23. https://doi.org/10.1161/01.STR.30.5.917
  25. Bhalla A, Wolfe CD, Rudd AG. Management of acute physiological parameters after stroke. QJM. 2001;94(3):167-72. https://doi.org/10.1093/qjmed/94.3.167
  26. Modo M, Stroemer RP, Tang E, Veizovic T, Sowniski P, Hodges H. Neurological sequelae and long-term behavioural assessment of rats with transient middle cerebral artery occlusion. J Neurosci Methods. 2000;104(1):99-109. https://doi.org/10.1016/S0165-0270(00)00329-0
  27. Lee CZ, Litt L, Hashimoto T, Young WL. Physiologic monitoring and anesthesia considerations in acute ischemic stroke. J Vasc Interv Radiol. 2004;15(1 Pt 2):S13-9. https://doi.org/10.1097/01.RVI.0000108689.13952.32
  28. Perkin GD, Murray-Lyon I. Neurology and the gastrointestinal system. J Neurol Neurosurg Psychiatry. 1998;65(3):291-300. https://doi.org/10.1136/jnnp.65.3.291
  29. Paczynski RP, Venkatesan R, Diringer MN, He YY, Hsu CY, Lin W. Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. Stroke. 2000;31(7):1702-8. https://doi.org/10.1161/01.STR.31.7.1702
  30. Pulsinelli W. Pathophysiology of acute ischaemic stroke. Lancet. 1992;339(8792):533-6. https://doi.org/10.1016/0140-6736(92)90347-6
  31. Ting P, Masaoka H, Kuroiwa T, Wagner H, Fenton I, Klatzo I. Influence of blood-brain barrier opening to proteins on development of post-ischaemic brain injury. Neurol Res. 1986;8(3):146-51.
  32. Klatzo I. Blood-brain barrier and ischaemic brain oedema. Z Kardiol. 1987;76:67-9.
  33. Klatzo I. Pathophysiological aspects of brain edema. Acta Neuropathol. 1987;72(3):236-9. https://doi.org/10.1007/BF00691095
  34. Kuroiwa T, Ting P, Martinez H, Klatzo I. The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol. 1985;68(2):122-9. https://doi.org/10.1007/BF00688633
  35. Kuroiwa T, Cahn R, Juhler M, Goping G, Campbell G, Klatzo I. Role of extracellular proteins in the dynamics of vasogenic brain edema. Acta Neuropathol. 1985;66(1):3-11. https://doi.org/10.1007/BF00698288