Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Cardiac Troponin I Elevation in Patients with Aneurysmal Subarachnoid Hemorrhage

  • Jeon, Ik-Chan (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Chang, Chul-Hoon (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Choi, Byung-Yon (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Min-Su (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Sang-Woo (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Seong-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University)
  • Published : 2009.08.28
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Abstract

Objective: Cardiac dysfunction after aneurysmal subarachnoid hemorrhage (SAH) is associated with elevation of serum cardiac troponin I (cTnl) levels. Elevation of cTnl predicts cardiopulmonary and neurological complications, and poor outcome. Methods: We retrospectively reviewed the medical and radiologic records of 114 (male: 30, female: 84) patients who developed aneurysmal SAH between January 2006 and June 2007 and had no history of previous cardiac problems. We evaluated their electrocardiography and cTnl level, which had been measured at admission. A cTnl level above 0.5 $\mu$g/L was defined as an indicator of cardiac injury following SAH. We examined various clinical factors for their association with cTnl elevation and analyzed data using chi-square test, t-test and logistic regression test with SPSS version 12.0. The results were considered significant at p< 0.05. Results: The following parameters shows a correlation with cTnl elevation: higher Hunt-Hess (H-H) grade (p = 0.000), poor Glasgow Outcome Scale (GOS) score (p = 0.000), profound pulmonary complication (p = 0.043), higher heart rate during initial three days following SAH (p = 0.029), ruptured aneurysm on communicating segment of internal carotid artery (p = 0.025), incidence of vasospasm (p = 0.421), and duration of hyperdynamic therapy for vasospasm (p = 0.292). A significant determinants for outcome were cTnl elevation (p = 0.046) and H-H grade (p = 0.000) in a multivariate study. Conclusion: A cTnl is a good indicator for cardiopulmonary and neurologic complications and outcome following SAH. Consideration of variable clinical factors that related with cTnl elevation may be useful tactics for treatment of SAH and concomitant complications.

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