Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
권호 표지

Platelet BDNF Level in Patients with Acute Bipolar Manic Episode : The Preliminary Study

급성 조증 환자에서 혈소판 BDNF 농도에 대한 예비 연구

  • Choi, Kwang-Yeon (Department of Psychiatry, Korea University College of Medicine, Ansan Hospital) ;
  • Kim, Yong-Ku (Department of Psychiatry, Korea University College of Medicine, Ansan Hospital) ;
  • Lee, Bun-Hee (Department of Psychiatry, Korea University College of Medicine, Ansan Hospital)
  • 최광연 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 김용구 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 이분희 (고려대학교 의과대학 안산병원 정신과학교실)
  • Published : 2009.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : Serum and plasma BDNF levels have been shown to be decreased in patients with mood disorder such as major depressive disorder and bipolar disorder. We investigated whether platelet BDNF levels would be lower in patients with acute bipolar manic episode compared with those of normal controls. Methods : BDNF levels were examined in platelet-rich plasma(PRP) and platelet-poor plasma(PPP) in 20 healthy controls and 20 hospitalized patients who were diagnosed as bipolar I disorder, most recent episode manic using a Structured Clinical Interview for DSM-IV. And severity of manic symptoms was measured using Young Mania Rating Scale(YMRS). Platelet BDNF level was calculated by subtracting PPP BDNF from PRP BDNF level, and dividing the result by the total platelet count, and it was expressed as pg/$10^6$ platelet. Results : Platelet BDNF levels were significantly lower in patients with acute bipolar manic episode(4.55${\pm}$3.36pg/$10^6$ platelet) than in normal controls(6.84${\pm}$2.32pg/$10^6$ platelet)(p=0.008). However we failed to reveal the significant negative correlation between platelet BDNF levels and YMRS scores in patients with acute bipolar episode. Conclusion : Our finding suggests that there is a decrease in the platelet BDNF of patients with acute bipolar manic episode.

Keywords