Abstract
The present study was performed to validate an analytical method for veterinary drugs, including amoxicillin, ampicillin, oxolinic acid and flumequin, in meat, fish, and their products as established in the 2007 Korea Food Code, and to monitor the respective drugs in 6 kinds of foods, namely beef, pork, flatfish, rockfish, freshwater eel and shrimp. Additionally, an HPLC-ESI-MS/MS method was developed for the qualification of these veterinary drugs. As a result of monitoring, these drugs were detected in 14 (3.6%) out of 393 samples. In particular, amoxicillin was detected in 9 flatfish samples, and oxolinic acid and flumequin were detected in 4 samples and 1 sample of freshwater eel, respectively. The detection levels of amoxicillin ranged from 0.009 to 0.078 mg/kg, in which 1 sample of flatfish contained more than the MRL (0.05 mg/kg). Flumequin detected in 1 sample of freshwater eel, was less than the MRL (0.5 mg/kg). Therefore, the majority of detected levels were less than the MRLs, with the exception of 2 samples showing amounts that were 1-2 times higher than the MRLs. The detected veterinary drugs were identified and confirmed by the HPLC-ESI-MS/MS method created in this study.
본 연구에서 확립한 분석법으로 총 393건의 시료를 분석한 결과 넙치에서 아목시실린 9건, 장어에서 옥소린산 4건과 플루메퀸 1건이 검출되었다. 아목시실린의 검출농도는 0.009-0.078 mg/kg의 범위를 나타내었고, 옥소린산의 검출농도는 0.02-0.20 mg/kg의 범위를 나타내었다. 플루메퀸은 잔류허용기준(0.5 mg/kg) 이하의 농도로 장어 1건(0.03 mg/kg)에서 검출되었다.
