Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Study of Antibacterial Activity of Some Novel 8-Methoxy-4-methyl-quinoline Derivatives

  • Singh, Sheoraj (Medicinal Chemistry Division, Department of Pharmacology, L. L. R. M. Medical College) ;
  • Kumar, Vikas (Medicinal Chemistry Division, Department of Pharmacology, L. L. R. M. Medical College) ;
  • Kumar, Ashok (Medicinal Chemistry Division, Department of Pharmacology, L. L. R. M. Medical College) ;
  • Sharma, Shalabh (Department of Chemistry, D. J. College of Engineering & Technology) ;
  • Dua, Piyush (Centre for Superfunctional Materials, Pohang University of Science and Technology)
  • Received : 2010.04.12
  • Accepted : 2010.09.29
  • Published : 2010.12.20
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Abstract

In the present study, some quinoline derivatives have been synthesized like 8-methoxy-4-methyl-2-amino-(3'-chloro-2'-oxo-4'-substituted aryl-1'-azetidinyl)quinolines 8-12 and 8-methoxy-4-methyl-2-amino-(2'-substituted aryl-4'-oxo-1',3'-thiazolidin-3'-yl) quinolines 13-17 from 8-methoxy-4-methyl-2-(substituted arylidenyliminoamino)-quinolines 3-7. The structural assignments of these compounds were based on spectral (IR, $^1H$-NMR, Mass) and elemental (C, H, N) analysis. Further, these compounds were evaluated for antibacterial activity against various bacterial strains. Three compounds 10, 11 and 16 were found to exhibit potent antibacterial activity as compared to the standard drug amphicillin.

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References

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