Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Beneficial Role of Ginseng Saponin on Hemodynamic Functions of Porcine Blood Vessel

  • Kim, Hyoung-Bae (Department of Veterinary Physiology, Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University) ;
  • Kang, Chang-Won (Department of Veterinary Physiology, Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Bum-Seok (Department of Veterinary Pathology, College of Veterinary Medicine, Chonbuk National University) ;
  • Kwon, Jung-Kee (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University) ;
  • Yu, Il-Jeoung (Department of Theriogenology and Obstetrics, College of Veterinary Medicine, Chonbuk National University) ;
  • Roh, Yoon-Seok (Department of Veterinary Pathology, College of Veterinary Medicine, Chonbuk National University) ;
  • Nah, Seung-Yeol (Department of Physiology, College of Veterinary Medicine, Konkuk University) ;
  • Ejaz, Sohail (Department of Clinical Neurosciences, Neurology Unit, Addenbrooke's Hospital, University of Cambridge) ;
  • Kim, Jong-Hoon (Department of Veterinary Physiology, Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University)
  • Received : 2010.07.23
  • Accepted : 2010.08.27
  • Published : 2010.12.29
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Abstract

The previous reports have showed that ginseng saponins, which are the active ingredients of Panax ginseng, cause the relaxation of artery that are contracted due to a various of hormones or potassium ($K^+$). Recently, we also showed that ginsenosides differentially regulate channel activity. The purpose of this study was to examine whether ginseng saponins affect contraction induced by $K^+$, serotonin (5-HT), or acetylcholine (Ach) in porcine coronary vessel. Treatment with concentrations of ginseng saponins caused a relaxation of 25 mM KCl-induced porcine coronary artery contraction. Also, ginseng saponin induced a significant dose-dependent relaxation of $3\;{\mu}M$ 5-HT-induced porcine coronary artery with the endothelium. In the porcine artery with the endothelium, ginseng saponins induced a relaxation by $3\;{\mu}M$ 5-HT in a concentration-dependent pattern. Ginseng saponins induced relaxation of both 25 mM KCl- and $3\;{\mu}M$ 5-HT-induced coronary artery contraction in the absence and presence of the endothelium. In contrast, treatment with $100\;{\mu}g/mL$ ginseng saponin did not induce relaxation in coronary artery contraction induced by Ach ($0.01\;{\mu}M$ to $30\;{\mu}M$) in the presence of the endothelium, but did cause significant relaxation of coronary artery contractions by Ach ($0.01\;{\mu}M$ to $30\;{\mu}M$) in the absence of the endothelium. These findings indicate that ginseng saponin (> $100\;{\mu}g/mL$) significantly inhibits porcine coronary artery contractions caused by $K^+$, 5-HT, and Ach. Therefore, in this study, we demonstrated that ginseng saponin may show beneficial roles on abnormal coronary contraction.

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References

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