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Ingestion of Korean Red Ginseng after Noise Exposure Can Potentiate Rapid Recovery of Hearing in Mice

  • Kang, Woo-Seok (Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Chung, Jong-Woo (Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2010.08.16
  • Accepted : 2010.11.18
  • Published : 2010.12.29

Abstract

One mechanism of inner ear damage by noise-induced hearing loss (NIHL) is the production of reactive oxygen species (ROS). Because Korean red ginseng (KRG) has an anti-ROS effect in various tissues, KRG may have a role in preventing NIHL. A window period exists in which ROS formations continue after noise exposure, and further damage can be prevented by antioxidants. In this study, we aimed to investigate the effects of KRG after exposure to noise. KRG (200 mg/kg) was fed to mice for 3 days after noise exposure. The change in hearing level was analyzed by measuring the auditory brainstem response. To induce a temporary threshold shift (TTS) of hearing, mice were exposed to 110 dB white noise for 3 hours. Fast recovery of hearing was observed in mice fed KRG 1 hour and 1 day after noise exposure for 3 days. The expression of 8-oxoguanine was not observed in the inner ears of mice fed KRG 1 hour after noise exposure, but was evident in the stria vascularis of mice in the control group (noise exposure only). From this study, we conclude that KRG acted as an effective inhibitor of NIHL in TTS cases.

Keywords

References

  1. Yamane H, Nakai Y, Takayama M, Konishi K, Iguchi H, Nakagawa T, Shibata S, Kato A, Sunami K, Kawakatsu C. The emergence of free radicals after acoustic trauma and strial blood flow. Acta Otolaryngol Suppl 1995;519:87-92.
  2. Ohlemiller KK, Wright JS, Dugan LL. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 1999;4:229-236. https://doi.org/10.1159/000013846
  3. Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Res 2000;878:163-173. https://doi.org/10.1016/S0006-8993(00)02733-5
  4. Ogita K, Matsunobu T, Schacht J. Acoustic trauma enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear. Neuroreport 2000;11:859-862. https://doi.org/10.1097/00001756-200003200-00040
  5. Jacono AA, Hu B, Kopke RD, Henderson D, Van De Water TR, Steinman HM. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 1998;117:31-38. https://doi.org/10.1016/S0378-5955(97)00214-1
  6. Yamasoba T, Harris C, Shoji F, Lee RJ, Nuttall AL, Miller JM. Influence of intense sound exposure on glutathione synthesis in the cochlea. Brain Res 1998;804:72-78. https://doi.org/10.1016/S0006-8993(98)00660-X
  7. Hu BH, Zheng XY, McFadden SL, Kopke RD, Henderson D. R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla. Hear Res 1997;113:198-206. https://doi.org/10.1016/S0378-5955(97)00143-3
  8. Yamasoba T, Schacht J, Shoji F, Miller JM. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo. Brain Res 1999;815:317-325. https://doi.org/10.1016/S0006-8993(98)01100-7
  9. Ohinata Y, Yamasoba T, Schacht J, Miller JM. Glutathione limits noise-induced hearing loss. Hear Res 2000;146:28-34. https://doi.org/10.1016/S0378-5955(00)00096-4
  10. Shim HJ, Kang HH, Ahn JH, Chung JW. Retinoic acid applied after noise exposure can recover the noise-induced hearing loss in mice. Acta Otolaryngol 2009;129:233-238. https://doi.org/10.1080/00016480802226155
  11. Yamashita D, Jiang HY, Schacht J, Miller JM. Delayed production of free radicals following noise exposure. Brain Res 2004;1019:201-209. https://doi.org/10.1016/j.brainres.2004.05.104
  12. Yamashita D, Jiang HY, Le Prell CG, Schacht J, Miller JM. Post-exposure treatment attenuates noise-induced hearing loss. Neuroscience 2005;134:633-642. https://doi.org/10.1016/j.neuroscience.2005.04.015
  13. Kin YR, Lee E, Lee SY, Kim KM. Effects of Panax ginseng on type I hypersensitivity. Korean J Ginseng Sci 1996;20:1-6.
  14. Sung MK, Kendall CW, Rao AV. Effect of soybean saponins and gypsophila saponin on morphology of colon carcinoma cells in culture. Food Chem Toxicol 1995;33:357-366. https://doi.org/10.1016/0278-6915(95)00007-O
  15. Ahn JH, Kim TS, Chung H, Lee N, Chung JW. The protective effect of orally ingested Korean red ginseng on the noise induced hearing loss in mice. J Ginseng Res 2009;33:104-110. https://doi.org/10.5142/JGR.2009.33.2.104
  16. Lee HY. A clinical audiological survey of noise-induced hearing loss. Korean J Otolaryngol 1971;14:21-31.
  17. Kim HJ. Noise-induced hearing loss. In: Noh GT. Otolaryngology: head and neck surgery. Seoul: Ilchokak, 2002. p.690-697.
  18. Spoendlin H. Histopathology of noise deafness. J Otolaryngol 1985;14:282-286.
  19. Axelsson A, Vertes D, Miller J. Immediate noise effects on cochlear vasculature in the guinea pig. Acta Otolaryngol 1981;91:237-246. https://doi.org/10.3109/00016488109138504
  20. Liu Z. Experimental study on the mechanism of free radical in blast trauma induced hearing loss. Zhonghua Er Bi Yan Hou Ke Za Zhi 1992;27:24-26.
  21. Seidman MD, Shivapuja BG, Quirk WS. The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage. Otolaryngol Head Neck Surg 1993;109:1052-1056. https://doi.org/10.1177/019459989310900613
  22. Chon KM. Audiological study on the hearing acuity of noise industrial worker. J Busan Med Assoc 1980;16:11-22.
  23. Hsu CJ, Chen YS, Shau WY, Yeh TH, Lee SY, Lin-Shiau SY. Impact of activities of Na(+)-K(+)-ATPase and Ca2(+)-ATPase in the cochlear lateral wall on recovery from noise-induced temporary threshold shift. Ann Otol Rhinol Laryngol 2002;111:842-849. https://doi.org/10.1177/000348940211100915

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