대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제31권4호
  • /
  • Pages.259-268
  • /
  • 2010
  • /
  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
DOI QR코드

DOI QR Code

유방촬영전용 양전자단층촬영시스템

Breast-dedicated Positron Emission Tomography Systems

  • 윤현석 (서울대학교 의과대학 핵의학교실) ;
  • 이찬미 (서울대학교 의과대학 핵의학교실) ;
  • 이또우 미끼꼬 (서울대학교 의과대학 핵의학교실) ;
  • 권순일 (서울대학교 의과대학 핵의학교실) ;
  • 김수미 (서울대학교 의과대학 핵의학교실) ;
  • 고근배 (서울대학교 의과대학 핵의학교실) ;
  • 이동수 (서울대학교 의과대학 핵의학교실) ;
  • 홍성종 (을지대학교 방사선학과) ;
  • 이재성 (서울대학교 의과대학 핵의학교실)
  • Yoon, Hyun-Suk (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Lee, Chan-Mi (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Ito, Mikiko (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Kwon, Sun-Il (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Kim, Soo-Mee (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Ko, Guen-Bae (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Lee, Dong-Soo (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Hong, Seong-Jong (Department of Radiological Science, Eulji University) ;
  • Lee, Jae-Sung (Department of Nuclear Medicine, Seoul National University College of Medicine)
  • 투고 : 2010.08.23
  • 심사 : 2010.08.26
  • 발행 : 2010.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Breast cancer is the most prevalent woman cancer, and its prevalence rate is increasing rapidly. It is necessary to develop the breast-dedicated positron emission tomography (PET) or positron emission mammography (PEM) systems with high resolution and sensitivity to improve the accuracy of diagnosis of breast cancer. Therefore, it is necessary to develop the high-end PET system technologies, such as the measurement of depth-of-interaction (DOI) and fully digitalized data acquisition, to establish high performance breast imaging systems. In this paper, recent technical advances in breast-dedicated PET imaging systems will be reviewed.

키워드

과제정보

연구 과제 주관 기관 : 과학재단

참고문헌

  1. W. H. Lee, and I. R. Yoo, "The role of fluorodeoxyglucose PET in the management of breast cancer," Hanyang Medical Review. vol. 28, no. 4, pp. 43-51, 2007.
  2. F. Benard, and E. Turcotte, "Imaging in breast cancer: Single-photon computed tomography and positron-emission tomography," Breast Cancer Res., vol. 7, no. 4, pp. 153-162, 2005. https://doi.org/10.1186/bcr1201
  3. Z. Cheng, O. P. De Jesus, M. Namavari, A. De, J. Levi, J. M. Webster, et al., "Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules," J. Nucl. Med., vol. 49, no. 5, pp. 804-813, 2008. https://doi.org/10.2967/jnumed.107.047381
  4. N. Avril, C. A. Rose, M. Schelling, J. Dose, W. Kuhn, S. Bense, et al., "Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: use and limitations," J. Clin. Oncol., vol. 18, no. 20, pp. 3495-3502, 2000. https://doi.org/10.1200/JCO.2000.18.20.3495
  5. S. E. Derenzo, W. W. Moses, H. G. Jackson, B. T. Turko, J. L. Cahoon, A. B. Geyer, and T. Vuletich, "Initial Characterization of a position-sensitive photodiode BGO detector for PET," IEEE Trans. Nucl. Sci., vol. 36, no. 1, pp. 1084-1089, 1989. https://doi.org/10.1109/23.34609
  6. W. W. Moses, "Trends in PET imaging," Nucl. Instrum. Meth. A, vol. 471, no. 1-2, pp. 209-214, 2001. https://doi.org/10.1016/S0168-9002(01)00969-X
  7. J. S. Kim, J. S. Lee, K. C. Im, S. J. Kim, S. Y. Kim, D. S. Lee, and D. H. Moon, "Performance measurement of the microPET focus 120 scanner," J. Nucl. Med., vol. 48, no. 9, pp. 1527-1535, 2007. https://doi.org/10.2967/jnumed.107.040550
  8. S. J. Hong, S. Il Kwon, M. Ito, G. S. Lee, K. S. Sim, K. S. Park, J. T. Rhee, and J. S. Lee, "Concept verification of three-layer DOI detectors for small animal PET," IEEE Trans. Nucl. Sci., vol. 55, no. 3, pp. 912-917, 2008. https://doi.org/10.1109/TNS.2008.920258
  9. J. S. Lee, "Technical advances in current PET and hybrid imaging systems," Open Nucl. Med. J., 2010. [In press]
  10. R. Fontaine, F. Belanger, N. Viscogliosi, H. Semmaoui, M. A. Tetrault, J. B. Michaud, C. Pepin, J. Cadorette, and R. Lecomte, "The hardware and signal processing architecture of LabPET (TM), a small animal APD-based digital PET scanner," IEEE Trans. Nucl. Sci., vol. 56, no. 1, pp. 3-9, 2009. https://doi.org/10.1109/TNS.2008.2007485
  11. G. C. Wang, J. S. Huber, W. W. Moses, J. Qi, and W. S. Choong, "Characterization of the LBNL PEM camera," IEEE Trans. Nucl. Sci., vol. 53, no. 3, pp. 1129-1135, 2006. https://doi.org/10.1109/TNS.2006.874956
  12. M. C. Abreu, D. Aguiar, E. Albuquerque, F. G. Almeida, P. Almeida, P. Amaral, et al., "Clear-PEM: A PET imaging system dedicated to breast cancer diagnostics," Nucl. Instrum. Meth. A, vol. 571, no. 1-2, pp. 81-84, 2007. https://doi.org/10.1016/j.nima.2006.10.034
  13. M. C. Abreu, J. D. Aguiar, F. G. Almeida, P. Almeida, P. Bento, B. Carrico, et al., "Design and evaluation of the Clear-PEM scanner for positron emission mammography," IEEE Trans. Nucl. Sci., vol. 53, no. 1, pp. 71-77, 2006. https://doi.org/10.1109/TNS.2006.870173
  14. G. Muehllehner, "Letter: Resolution limit of positron cameras," J. Nucl. Med., vol. 17, no. 8, pp. 757-758, 1976.
  15. W. W. Moses, and J. Qi, "Fundamental limits of positron emission mammography," Nucl. Instrum. Meth. A, vol. 497, no. 1, pp. 82-89, 2003. https://doi.org/10.1016/S0168-9002(02)01895-8
  16. R. R. Raylman, S. Majewski, M. F. Smith, J. Proffitt, W. Hammond, A. Srinivasan, et al., "The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements," Phys. Med. Biol., vol. 53, no. 3, pp. 637-653, 2008. https://doi.org/10.1088/0031-9155/53/3/009
  17. S. L. Bowen, S. R. Cherry, J. M. Boone, and R. D. Badawi, "Monte Carlo simulation study of several camera designs for the PET component of a dedicated breast PET/CT scanner," Eur. J. Nucl. Med. Mol. Imaging, vol. 33, no., pp. S117-S117, 2006. https://doi.org/10.1007/s00259-005-1899-4
  18. J. Y. Qi, R. M. Leahy, S. R. Cherry, A. Chatziioannou, and T. H. Farquhar, "High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner," Phys. Med. Biol., vol. 43, no. 4, pp. 1001-1013, 1998. https://doi.org/10.1088/0031-9155/43/4/027
  19. S. Surti, and J. S. Karp, "Design considerations for a limited angle, dedicated breast, TOF PET scanner," Phys. Med. Biol., vol. 53, no. 11, pp. 2911-2921, 2008. https://doi.org/10.1088/0031-9155/53/11/010
  20. K. Kitamura, and H. Kudo. "MAP-EM reconstruction using uniform background template for limited-angle PEM," IEEE Nuclear Science Symposium Conference Record, 2008.
  21. S. L. Bowen, Y. Wu, A. J. Chaudhari, L. Fu, N. J. Packard, G. W. Burkett, et al., "Initial characterization of a dedicated breast PET/CT scanner during human imaging," J. Nucl. Med., vol. 50, no. 9, pp. 1401-1408, 2009. https://doi.org/10.2967/jnumed.109.064428
  22. B. Ravindranath, S. H. Maramraju, S. S. Junnarkar, S. S. Southekal, S. P. Stoll, J. F. Pratte, et al., "A Simultaneous PET/MRI breast scanner based on the RatCAP," IEEE Nuclear Science Symposium Conference Record, 2008.
  23. C. G. Berman, "Recent advances in breast-specific imaging," Cancer Control, vol. 14, no. 4, pp. 338-349, 2007. https://doi.org/10.1177/107327480701400404
  24. M. Furuta, et al. "Basic evaluation of a C-shaped breast PET scanner," IEEE Nuclear Science Symposium Conference Record, 2009.
  25. Y. H. Chung, Y. Choi, G. Cho, Y. S. Choe, K. H. Lee, and B. T. Kim, "Characterization of dual layer phoswich detector performance for small animal PET using Monte Carlo simulation," Phys. Med. Biol., vol. 49, no. 13, pp. 2881-2890, 2004. https://doi.org/10.1088/0031-9155/49/13/008
  26. Y. H. Chung, S. J. Lee, C. H. Baek, and Y. Choi, "New design of a quasi-monolithic detector module with DOI capability for small animal PET," Nucl. Instrum. Meth. A, vol. 593, no. 3, pp. 588-591, 2008. https://doi.org/10.1016/j.nima.2008.05.059
  27. S. J. Lee, C. H. Baek, Y. H. Chung, Y. Choi, and W. Lee, "A cross-stack quasi-monolithic detector with DOI capability for a small animal PET," J. Korean Phys. Soc., vol. 54, no. 6, pp. 2429-2434, 2009. https://doi.org/10.3938/jkps.54.2429
  28. J. S. Lee, M. Ito, K. S. Sim, B. Hong, K. S. Lee, J. Muhammad, et al., "Investigation of solid-state photomultipliers for positron emission tomography scanners," J. Korean Phys. Soc., vol. 50, no. 5, pp. 1332-1339, 2007. https://doi.org/10.3938/jkps.50.1332
  29. S. J. Hong, I. C. Song, M. Ito, S. I. Kwon, G. S. Lee, K. S. Sim, K. S. Park, J. T. Rhee, and J. S. Lee, "An investigation into the use of Geiger-mode solid-state photomultipliers for simultaneous PET and MRI acquisition," IEEE Trans. Nucl. Sci., vol. 55, no. 3, pp. 882-888, 2008. https://doi.org/10.1109/TNS.2008.924082
  30. J. S. Lee, and S. J. Hong Geiger-mode avalanche photodiodes for PET/MRI. In: Iniewski K, eds. Electronic Circuits for Radiation Detection. CRC Press LLC, 2010, pp. 179-200.
  31. S. I. Kwon, J. S. Lee, H. S. Yoon, M. Ito, G. B. Ko, J. Y. Choi, S-H. Lee, I. C. Song, J. M. Jeong, D. S. Lee, and S. J. Hong, "Development of small animal PET prototype using a Geiger-mode APD: Initial results of phantom and animal imaging studies", J. Nucl. Med., [Submitted]
  32. J. H. Jung, Y. Choi, K. J. Hong, W. Hu, J. Kang, B. J. Min, S. H. Shin, H. K. Lim, Y. S. Huh, and E. J. Kim, "Development of a position decoder circuit for PET consisting of GAPD arrays," Nucl. Instrum. Meth. A, vol. 621, no. 1-3, pp. 310-315, 2010. https://doi.org/10.1016/j.nima.2010.04.028
  33. M. Ito, J. S. Lee, M. J. Park, K. S. Sim, and S. J. Hong, "Design and simulation of a novel method for determining depth-of- interaction in a PET scintillation crystal array using a single- ended readout by a multi-anode PMT," Phys. Med. Biol., vol. 55, no. 13, pp. 3827-3841, 2010. https://doi.org/10.1088/0031-9155/55/13/017
  34. W. W. Moses, S. E. Derenzo, C. L. Melcher, and R. A. Manente, "Room-temperature LSO PIN photodiode PET detector module that measures depth of interaction," IEEE Trans. Nucl. Sci., vol. 42, no. 4, pp. 1085-1089, 1995. https://doi.org/10.1109/23.467744
  35. Y. Shao, R. W. Silverman, R. Farrell, L. Cirignano, R. Grazioso, K. S. Shah, et al., "Design studies of a high resolution PET detector using APD arrays," IEEE Trans. Nucl. Sci., vol. 47, no. 3, pp. 1051-1057, 2000. https://doi.org/10.1109/23.856546
  36. Y. F. Yang, Y. B. Wu, J. Y. Qi, S. S. James, H. N. Du, P. A. Dokhale, K. S. Shah, R. Farrell, and S. R. Cherry, "A prototype PET scanner with DOI-encoding detectors," J. Nucl. Med., vol. 49, no. 7, pp. 1132-1140, 2008. https://doi.org/10.2967/jnumed.107.049791
  37. H. R. Cho, S. M. Kim, and J. S. Lee, "Parameter analysis for relaxed OS-SPS algorithm for image reconstruction," Spring Symposium of Korean Society of Medical and Biological Engineering. 2009.
  38. H. S. Kim, S. M. Kim, H. R. Cho, and J. S. Lee, "Comparison of MAP reconstruction algorithms and prior functions for gap compensation in animal PET," Fall Symposium of Korean Society of Medical and Biological Engineering. 2009.
  39. S. M. Ahn, S. M. Kim, and J. S. Lee, "ART reconstruction of limited-angle data using constrained, total-variation minimization," Spring Symposium of Korean Society of Medical and Biological Engineering. 2010.
  40. B. J. Pichler, M. S. Judenhofer, C. Catana, J. H. Walton, M. Kneilling, R. E. Nutt, S. B. Siegel, C. D. Claussen, and S. R. Cherry, "Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI," J. Nucl. Med., vol. 47, no. 4, pp. 639-647, 2006.
  41. H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, et al., "Simultaneous MR/PET imaging of the human brain: feasibility study," Radiology, vol. 248, no. 3, pp. 1028-1035, 2008. https://doi.org/10.1148/radiol.2483071927
  42. G. Delso, and S. Ziegler, "PET/MRI system design," Eur. J. Nucl. Med. Mol. Imaging, vol. 36 Suppl 1, no., pp. S86-92, 2009. https://doi.org/10.1007/s00259-008-1008-6
  43. H. F. Wehrl, M. S. Judenhofer, S. Wiehr, and B. J. Pichler, "Pre-clinical PET/MR: technological advances and new perspectives in biomedical research," Eur. J. Nucl. Med. Mol. Imaging, vol. 36 Suppl 1, no., pp. S56-68, 2009. https://doi.org/10.1007/s00259-009-1078-0
  44. M. Ito, J. S. Lee, S. Il Kwon, G. S. Lee, B. Hong, K. S. Lee, et al., "A four-layer DOI detector with a relative offset for use in an animal PET system," IEEE Trans. Nucl. Sci., vol. 57, no. 3, pp. 976-981, 2010. https://doi.org/10.1109/TNS.2010.2044892