Korean Journal of Poultry Science (한국가금학회지)

The Korean Society of Poultry Science (한국가금학회)
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Effects of Proanthocyanidin-rich Extract from Pinus radiata Bark on Immune Responses of Broiler Chickens

  • Park, In-Jae (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute) ;
  • Cha, Se-Yeoun (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute) ;
  • Kang, Min (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute) ;
  • So, Yang-Seop (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute) ;
  • Go, Hiw-Gon (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute) ;
  • Son, Young-Ho (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute) ;
  • Mun, Sung-Phil (Department of Wood Science & Technologyy, Chonbuk National University) ;
  • Ryu, Kyung-Seon (School of Animal Science & Biotechnology, Chonbuk National University) ;
  • Jang, Hyung-Kwan (Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine & Korea Zoonoses Research Institute)
  • Received : 2010.10.04
  • Accepted : 2010.11.01
  • Published : 2010.12.31
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Abstract

We evaluated the immunomodulatory effects of proanthocyanidin-rich extract (PAE) from Pinus radiata bark in broiler. Proliferation of peripheral blood mononuclear cells and thymocytes was significantly enhanced in 2.5, 5, 10 mg/kg PAE-treated broiler chickens. Proliferation of splenocytes was significantly enhanced in 1.25, 2.5, 5, 10 mg/kg PAE-treated broiler chickens. These effects were markedly enhanced by the presence of LPS, which acts on B cells responsible for humoral immunity, and Con A, which acts directly on T cells involved in cell mediated immunity. PAE significantly promoted the expression of interleukin-18 and interleukin-$1\beta$. Thus, PAE from P. radiata possesses immunomodulatory effects in broiler chickens.

Keywords

References

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