Membrane Journal (멤브레인)

The Membrane Society of Korea (한국막학회)
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Preparation of Polyurethane Diagnostic Membranes for Blood Glucose Measurements (6) : Effects of Hematocrit on Measurements of Glucose Concentration

혈당측정을 위한 폴리우레탄 진단막의 제조(6) : 헤마토크릿이 글루코우즈의 농도 측정에 미치는 영향

  • Kwon, Suk-Ky (Department of Biological and Chemical Engineering, Hongik University)
  • 권석기 (홍익대학교 과학기술대학 바이오화학공학과)
  • Received : 2010.08.09
  • Accepted : 2010.09.03
  • Published : 2010.09.30
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Abstract

Polyurethane diagnostic membranes were prepared to measure blood glucose level of diagnostics. Final absorbances at 680 nm through activated polyurethane membranes were measured at various concentration of glucose in blood. The end-point results of varing absorbance values as time (K/S) was found to have a linear relationship toward the blood glucose concentration. The effects of hematocrit on the glucose concentration measurements were examined. In low hematocrit, dose-response slope (DRS) values between gluose concentration and K/S values did not show the big differences compared to those in plasma. However, in high hematocrit (more than 40%) DRS values were considerably decreased.

당뇨병 환자의 혈당치 측정을 위하여 폴리우레탄으로 만들어진 진단막을 제조하였다. 혈액 속의 글루코우즈의 농도를 변화시켜가며 폴리우레탄 진단막을 가지고 680 nm에서의 최종흡광도를 측정하였다. 시간에 따른 흡광도 변화량(K/S)의 최종 결과치가 글루코우즈의 농도가 증가함에 따라 직선적으로 증가하였다. 헤마토크릿이 글루코우즈의 농도 측정에 미치는 영향을 조사하였다. 낮은 헤마토크릿에서는 글루코우즈의 농도와 K/S와의 기울기 값(Dose-Response Slope : DRS)이 플라즈마와 비교해 큰 차이를 보이지 않았다. 그러나 높은 헤마토크릿(40% 이상)에서는 상당히 감소함을 알 수 있었다.

Keywords

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