Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Anti-obesity effects of onion juice in high fat diet-induced obese rats

비만 유도 흰쥐에 대한 양파의 항비만 효과

  • Kang, Won Young (College of Veterinary Medicine, Jeju National University) ;
  • Kim, Mun Yong (College of Veterinary Medicine, Jeju National University) ;
  • Jin, Ju Youn (College of Veterinary Medicine, Jeju National University) ;
  • Yang, Heekyoung (College of Veterinary Medicine, Jeju National University) ;
  • Hong, Hyun Ju (College of Veterinary Medicine, Jeju National University) ;
  • Kim, Dong Geon (College of Veterinary Medicine, Jeju National University) ;
  • Han, Chang-Hoon (College of Veterinary Medicine, Jeju National University) ;
  • Lee, Young Jae (College of Veterinary Medicine, Jeju National University)
  • 강원영 (제주대학교 수의과대학) ;
  • 김문용 (제주대학교 수의과대학) ;
  • 진주연 (제주대학교 수의과대학) ;
  • 양희경 (제주대학교 수의과대학) ;
  • 홍현주 (제주대학교 수의과대학) ;
  • 김동건 (제주대학교 수의과대학) ;
  • 한창훈 (제주대학교 수의과대학) ;
  • 이영재 (제주대학교 수의과대학)
  • Accepted : 2010.01.11
  • Published : 2010.03.30
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Abstract

This study investigated the effects of onion juice on the serum lipid components and blood pressure in obese rats fed high fat diets. Thirty-nine of Sprague-Dawley rats were divided into six groups, and were treated for 8 weeks: (1) normal diet (ND); (2) high fat diet (HFD); (3) HFD for first 4 weeks and high fat diet with 40% onion juice for the last 4weeks (H-H+O); (4) HFD with 40% onion juice for 8 weeks (H+O); (5) HFD for first 4 weeks and ND for the last 4 weeks (H-N); (6) HFD for first 4 weeks and ND with 40% onion juice for the last 4 weeks (H-N+O). The rates of increasing body weight were reduced in H+O and H-H+O groups compared with HFD group. The levels of triglyceride, low density lipoprotein-cholesterol and total cholesterol in blood serum were significantly decreased in the H+O and H-H+O groups compared with the HFD group. Administration of onion reduced the size of adipocyte, steatosis, and serum hyperlipidemia in obese rats fed HFD. Moreover, the antihypertensive effects of onion were observed in obesity rat fed HFD. Overall results suggest that onion reduces the serum lipid components and improves hypertension in obese rat fed HFD.

Keywords

References

  1. 강정애, 김정숙. 고 또는 저콜레스테롤 식이를 먹인쥐에 있어서 양파, 마늘이 체내 콜레스테롤과 중성지방 수준 및 혈소판 응집에 미치는 영향. 한국영양학회지 1997, 30, 132-138
  2. 김석영, 윤진순. 비만도와 혈청 인슐린 농도, 식사행동, 섭취열량과의 관련성. 한국영양학회지 1993, 26, 34-46
  3. 나경수, 정수현, 서형주, 손종연, 이효구. 양파 껍질에서 분리한 xanthine oxidase 저해물질. 한국식품과학회지 1998, 30, 697-701
  4. 박평심, 이병래, 이명렬. 양파식이가 흰쥐에서 사염화탄소 독성에 미치는 영향. 한국영양식량학회지 1991, 20, 121-125
  5. 박평심, 이병래, 이명렬. 양파즙이 에탄올에 의한 백서의 지질과산화물 생성에 미치는 영향. 한국영양식량학회지 1994, 23, 750-756
  6. 서화중, 정두례. 흰쥐에 양파즙 투여가 혈액 지질량에 미치는 영향. 한국식품영양과학회지 1997, 26, 1164-1172
  7. 손종연, 손흥수, 조원대. 양파껍질 추출물의 항산화및 상승효과. 한국조리과학회지 1998, 14, 16-20
  8. 이찬중, 김희대, 정은호, 서전규, 박철우, 하영래. 비상품 양파추출물의 Mouse 피부암 및 위장암 억제효과. 한국식품영양과학회지 2000, 29, 525-530
  9. Abate N. Insulin resistance and obesity. The role of fat distribution pattern. Diabetes Care 1996, 19, 292-294 https://doi.org/10.2337/diacare.19.3.292
  10. Babu PS, Srinivasan K. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol Cell Biochem 1997, 175, 49-57 https://doi.org/10.1023/A:1006881027166
  11. Babu PS, Srinivasan K. Renal lesions in streptozotocininduced diabetic rats maintained on onion and capsaicin containing diets. J Nutr Biochem 1999, 10, 477-483 https://doi.org/10.1016/S0955-2863(99)00031-5
  12. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994, 107, 1103-1109 https://doi.org/10.1016/0016-5085(94)90235-6
  13. Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 1997, 100, 3105-3110 https://doi.org/10.1172/JCI119865
  14. Carson JF. Chemistry and biological properties of onion and garlic. Food Rev Int 1987, 3, 71-103 https://doi.org/10.1080/87559128709540808
  15. Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation in apparently healthy men. Hypertension 2001, 38, 399-403 https://doi.org/10.1161/01.HYP.38.3.399
  16. Duarte J, Galisteo M, Ocete MA, Pérez-Vizcaino F, Zarzuelo A, Tamargo J. Effects of chronic quercetin treatment on hepatic oxidative status of spontaneously hypertensive rats. Mol Cell Biochem 2001, 221, 155-160 https://doi.org/10.1023/A:1010956928584
  17. Duarte J, P$\acute{e}$rez-Vizcaíno F, Zarzuelo A, Jim$\acute{e}$nez J, Tamargo J. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur J Pharmacol 1993, 239, 1-7 https://doi.org/10.1016/0014-2999(93)90968-N
  18. Duprez DA, Somasundaram PE, Sigurdsson G, Hoke L, Florea N, Cohn JN. Relationship between Creactive protein and arterial stiffness in an asymptomatic population. J Hum Hypertens 2005, 19, 515-519 https://doi.org/10.1038/sj.jhh.1001860
  19. Frémont L, Gozzélino MT, Franchi MP, Linard A. Dietary flavonoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. J Nutr 1998, 128, 1495-1502
  20. Ginsberg HN, Le NA, Gibson JC. Regulation of the production and catabolism of plasma low density lipoproteins in hypertriglyceridemic subjects. Effect of weight loss. J Clin Invest 1985, 75, 614-623 https://doi.org/10.1172/JCI111739
  21. Grundy SM, Mok HYI, Zech L, Steinberg D, Berman M. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J Clin Invest 1979, 63, 1274-1283 https://doi.org/10.1172/JCI109422
  22. Gryglewski RJ, Korbut R, Robak J, Swies J. On the mechanism of antithrombotic action of flavonoids. Biochem Pharmacol 1987, 36, 317-322 https://doi.org/10.1016/0006-2952(87)90288-7
  23. Hommels MJ, van der Ven AJAM, Kroon AA, Kessels AGH, Van Dieijen-Visser MP, Van Engelshoven JAM, Bruggeman CA, De Leeuw PW. C-reactive protein, atherosclerosis and kidney function in hypertensive patients. J Hum Hypertens 2005, 19, 521-526 https://doi.org/10.1038/sj.jhh.1001878
  24. Howard BV. Insulin resistance and lipid metabolism. Am J Cardiol 1999, 84, 28J-32J
  25. Ilan E, Tirosh O, Madar Z. Triacylglycerol-mediated oxidative stress inhibits nitric oxide production in rat isolated hepatocytes. J Nutr 2005, 135, 2090-2095
  26. Kim JH. Anti-bacterial action of onion (Allium cepa L.) extracts against oral pathogenic bacteria. J Nihon Univ Sch Dent 1997, 39, 136-141 https://doi.org/10.2334/josnusd1959.39.136
  27. Kim JY, Nolte LA, Hansen PA, Han DH, Ferguson K, Thompson PA, Holloszy JO. High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass. Am J Physiol Regul Integr Comp Physiol 2000, 279, R2057-2065
  28. Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK, Adams PW. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982, 54, 254-260 https://doi.org/10.1210/jcem-54-2-254
  29. Krotkiewski M, Björntorp P, Sj$\ddot{o}$ström L, Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 1983, 72, 1150-1162 https://doi.org/10.1172/JCI111040
  30. Manach C, Morand C, Crespy V, Demign$\acute{e}$ C, Texier O, R$\acute{e}$g$\acute{e}$rat F, R$\acute{e}$m$\acute{e}$sy C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett 1998, 426, 331-336 https://doi.org/10.1016/S0014-5793(98)00367-6
  31. Morand C, Crespy V, Manach C, Besson C, Demign$\acute{e}$ C, R$\acute{e}$m$\acute{e}$sy C. Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol Regul Integr Comp Physiol 1998, 275, R212-219
  32. Park YK. Source and processing technology of vegetable juices and the trend of study. Bull Food Technol 1995, 8, 59-68
  33. Sakai Y, Murakami T, Yamamoto Y. Antihypertensive effects of onion on NO synthase inhibitor-induced hypertensive rats and spontaneously hypertensive rats. Biosci Biotechnol Biochem 2003, 67, 1305-1311 https://doi.org/10.1271/bbb.67.1305
  34. Schillaci G, Pirro M, Gemelli F, Pasqualini L, Vaudo G, Marchesi S, Siepi D, Bagaglia F, Mannarino E. Increased C-reactive protein concentrations in nevertreated hypertension: the role of systolic and pulse pressures. J Hypertens 2003, 21, 1841-1846 https://doi.org/10.1097/00004872-200310000-00010
  35. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM. C-reactive protein and the risk of developing hypertension. JAMA 2003, 290, 2945-2951 https://doi.org/10.1001/jama.290.22.2945
  36. Sheela CG, Kumud K, Augusti KT. Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 1995, 61, 356-357 https://doi.org/10.1055/s-2006-958099
  37. Stumpf C, John S, Jukic J, Yilmaz A, Raaz D, Schmieder RE, Daniel WG, Garlichs CD. Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertension. J Hypertens. 2005, 23, 995-1000 https://doi.org/10.1097/01.hjh.0000166840.63312.12
  38. Roberts CK, Vaziri ND, Ni Z, Barnard RJ. Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modification. Atherosclerosis 2002, 163, 321-327 https://doi.org/10.1016/S0021-9150(02)00010-2
  39. Roberts CK, Vaziri ND, Wang XQ, Barnard RJ. Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet. Hypertension 2000, 36, 423-429 https://doi.org/10.1161/01.HYP.36.3.423
  40. Ruotolo G, Howard BV. Dyslipidemia of the metabolic syndrome. Curr Cardiol Rep 2002, 4, 494-500 https://doi.org/10.1007/s11886-002-0113-6
  41. Uygun A, Kadayifci A, Yesilova Z, Erdil A, Yaman H, Saka M, Deveci MS, Bagci S, Gulsen M, Karaeren N, Dagalp K. Serum leptin levels in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2000, 95, 3584-3589 https://doi.org/10.1111/j.1572-0241.2000.03297.x
  42. Wilde DW, Massey KD, Walker GK, Vollmer A, Grekin RJ. High-fat diet elevates blood pressure and cerebrovascular muscle $Ca2^{+}$ current. Hypertension 2000, 35, 832-837 https://doi.org/10.1161/01.HYP.35.3.832
  43. Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation 2004, 109, II2-10 https://doi.org/10.1161/01.CIR.0000122867.89751.59
  44. Yamamoto Y, Oue E. Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet. Biosci Biotechnol Biochem 2006, 70, 933-939 https://doi.org/10.1271/bbb.70.933