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Environmental tobacco smoke and childhood asthma

  • Song, Dae Jin (Department of Pediatrics, College of Medicine, Korea University)
  • Received : 2010.01.21
  • Accepted : 2010.01.27
  • Published : 2010.02.15

Abstract

In recent years, environmental tobacco smoke (ETS) has become an important worldwide public health issue. Children are particularly vulnerable to ETS because they are still developing. ETS exposure causes a wide range of adverse health effects on childhood asthma. There is convincing evidence that ETS exposure is causally associated with an increased prevalence of asthma, increased severity of asthma and worsening asthma control in children who already have the disease, even though a causal relationship with asthma onset is not yet established for asthma incidence. Mechanisms underlying these adverse effects of ETS are not clearly elucidated but e studies on this issue suggest that genetic susceptibility, impaired lung function, and augmented airway inflammation and remodeling may be involved. Children with asthma are just as likely to be exposed to ETS as children in general and there is no risk-free level of exposure. Therefore, providing a smoke-free environment may be of particular importance to the asthmatic children exposed to ETS who have adverse asthma outcomes, as well as to children with genetic susceptibility who are at increased risk of developing asthma upon exposure to ETS in early childhood.

Keywords

References

  1. U.S. EPA. Respiratory health effects of passive smoking: lung cancer and other disorders. Washington, DC: U.S. environmental protection agency; 1992. 525 p. Report no.: EPA/600/6-90/006F
  2. Besaratinia A, Pfeifer GP. Second-hand smoke and human lung cancer. Lancet Oncol 2008;9:657-66 https://doi.org/10.1016/S1470-2045(08)70172-4
  3. Tamburlini G, Ehrenstein Ov, Bertollini R, editors. Children's health and environment: a review of evidence. A joint report from the European environment agency and the WHO regional office for Europe. Luxembourg: European environment agency, 2002. 223 p.(Environmental issue report No 29)
  4. Warren CW, Jones NR, Eriksen MP, Asma S. Patterns of global tobacco use in young people and implications for future chronic disease burden in adults. Lancet 2006;367:749-53 https://doi.org/10.1016/S0140-6736(06)68192-0
  5. DiFranza JR, Aligne CA and Weitzman M. Prenatal and postnatal environmental tobacco smoke exposure and children's health. Pediatrics 2004;113:1007-15
  6. US Department of health and human services. The health consequences of involuntary exposure to tobacco smoke: A report of the surgeon general. Atlanta(GA):US Department of health and human services, 2006. Chapter 6, Respiratory effects in children from exposure to secondhand smoke: p. 257-420
  7. Mannino DM, Homa DM, Redd SC. Involuntary smoking and asthma severity in children: data from the Third National Health and Nutrition Examination Survey. Chest 2002;122:409-15 https://doi.org/10.1378/chest.122.2.409
  8. Strachan DP, Cook DG. Health effects of passive smoking. 6. Parental smoking and childhood asthma: longitudinal and case-control studies. Thorax 1998;53:204-12 https://doi.org/10.1136/thx.53.3.204
  9. Cook DG, Strachan DP. Health effects of passive smoking. 3. Parental smoking and prevalence of respiratory symptoms and asthma in school age children. Thorax 1997;52:1081-94 https://doi.org/10.1136/thx.52.12.1081
  10. Jaakkola JJ, Nafstad P, Magnus P. Environmental tobacco smoke, parental atopy, and childhood asthma. Environ Health Perspect 2001;109:579-82
  11. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995;332:133-8 https://doi.org/10.1056/NEJM199501193320301
  12. California environmental protection agency. Proposed identification of environmental tobacco smoke as toxic air contaminant. Part B: Health effects. Sacramento(CA): California environmental protection agency, 2006. 526 p
  13. Martinez FD, Cline M, Burrows B. Increased incidence of asthma in children of smoking mothers. Pediatrics 1992;89:21-6
  14. Weitzman M, Gortmaker S, Walker DK, Sobol A. Maternal smoking and childhood asthma. Pediatrics 1990;85:505-11
  15. Alati R, Al Mamun A, O'Callaghan M, Najman JM and Williams GM. In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology 2006;17:138-44 https://doi.org/10.1097/01.ede.0000198148.02347.33
  16. Jaakkola JJ, Gissler M. Maternal smoking in pregnancy, fetal development, and childhood asthma. Am J Public Health 2004;94:136-40 https://doi.org/10.2105/AJPH.94.1.136
  17. Strachan DP, Butland BK, Anderson HR. Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. BMJ 1996;312:1195-9
  18. Chen Y, Rennie DC, Dosman JA. Influence of environmental tobacco smoke on asthma in nonallergic and allergic children. Epidemiology 1996;7:536-9 https://doi.org/10.1097/00001648-199609000-00015
  19. Murray AB, Morrison BJ. It is children with atopic dermatitis who develop asthma more frequently if the mother smokes. J Allergy Clin Immunol 1990;86:732-9 https://doi.org/10.1016/S0091-6749(05)80177-0
  20. Hu FB, Persky V, Flay BR, Zelli A, Cooksey J, Richardson J. Prevalence of asthma and wheezing in public schoolchildren: association with maternal smoking during pregnancy. Ann Allergy Asthma Immunol 1997;79:80-4 https://doi.org/10.1016/S1081-1206(10)63090-6
  21. Pattenden S, Antova T, Neuberger M, Nikiforov B, De Sario M, Grize L, et al. Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure. Tob Control 2006;15:294-301 https://doi.org/10.1136/tc.2005.015065
  22. Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2001;163:429-36
  23. Song DJ, Kim HJ, Park SH, Choung JT. Effects of paternal tobacco smoking on children's pulmonary function and prevalence of asthma and lifetime wheezing episode. Pediatr Allergy Respir Dis (Korea) 2007;17:206-15
  24. Xepapadaki P, Manios Y, Liarigkovinos T, Grammatikaki E, Douladiris N, Kortsalioudaki C, et al. Association of passive exposure of pregnant women to environmental tobacco smoke with asthma symptoms in children. Pediatr Allergy Immunol 2009;20:423-9 https://doi.org/10.1111/j.1399-3038.2008.00820.x
  25. Shaw R, Woodman K, Crane J, Moyes C, Kennedy J, Pearce N. Risk factors for asthma symptoms in Kawerau children. N Z Med J 1994;107:387-91
  26. Soyseth V, Kongerud J, Boe J. Postnatal maternal smoking increases the prevalence of asthma but not of bronchial hyperresponsiveness or atopy in their children. Chest 1995;107:389-94 https://doi.org/10.1378/chest.107.2.389
  27. Cook DG, Strachan DP. Health effects of passive smoking- 10: Summary of effects of parental smoking on the respiratory health of children and implications for research. Thorax 1999;54:357-66 https://doi.org/10.1136/thx.54.4.357
  28. Hu FB, Persky V, Flay BR, Richardson J. An epidemiological study of asthma prevalence and related factors among young adults. J Asthma 1997;34:67-76 https://doi.org/10.3109/02770909709071205
  29. Chilmonczyk BA, Salmun LM, Megathlin KN, Neveux LM, Palomaki GE, Knight GJ, et al. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med 1993;328:1665-9 https://doi.org/10.1056/NEJM199306103282303
  30. Soussan D, Liard R, Zureik M, Touron D, Rogeaux Y, Neukirch F. Treatment compliance, passive smoking, and asthma control: a three year cohort study. Arch Dis Child 2003;88:229-33 https://doi.org/10.1136/adc.88.3.229
  31. Gilliland FD, Berhane K, Islam T, Wenten M, Rappaport E, Avol E, et al. Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren. Am J Epidemiol 2003;157:861-9 https://doi.org/10.1093/aje/kwg037
  32. Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002;57:226-30 https://doi.org/10.1136/thorax.57.3.226
  33. Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, et al. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med 2007;175:783-90 https://doi.org/10.1164/rccm.200511-1746OC
  34. Tomlinson JE, McMahon AD, Chaudhuri R, Thompson JM, Wood SF, Thomson NC. Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax 2005;60:282-7 https://doi.org/10.1136/thx.2004.033688
  35. Chaudhuri R, Livingston E, McMahon AD, Thomson L, Borland W, Thomson NC. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003;168:1308-11 https://doi.org/10.1164/rccm.200304-503OC
  36. Song DJ, Min MG, Miller M, Cho JY, Broide DH. Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen. Am J Physiol Lung Cell Mol Physiol 2009;297:L380-7 https://doi.org/10.1152/ajplung.90588.2008
  37. Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, et al. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med 2002;166:457-63 https://doi.org/10.1164/rccm.2112064
  38. Kabesch M, Hoefler C, Carr D, Leupold W, Weiland SK, von Mutius E. Glutathione S transferase deficiency and passive smoking increase childhood asthma. Thorax 2004;59:569-73 https://doi.org/10.1136/thx.2003.016667
  39. Dizier MH, Bouzigon E, Guilloud-Bataille M, Siroux V, Lemainque A, Boland A, et al. Evidence for gene x smoking exposure interactions in a genome-wide linkage screen of asthma and bronchial hyper-responsiveness in EGEA families. Eur J Hum Genet 2007;15:810-5 https://doi.org/10.1038/sj.ejhg.5201830
  40. Bouzigon E, Corda E, Aschard H, Dizier MH, Boland A, Bousquet J, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008;359:1985-94 https://doi.org/10.1056/NEJMoa0806604
  41. Colilla S, Nicolae D, Pluzhnikov A, Blumenthal MN, Beaty TH, Bleecker ER, et al. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 2003;111:840-6 https://doi.org/10.1067/mai.2003.170
  42. Meyers DA, Postma DS, Stine OC, Koppelman GH, Ampleford EJ, Jongepier H, et al. Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol 2005;115:1169-75 https://doi.org/10.1016/j.jaci.2005.01.070
  43. Li YF, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005;127:1232-41 https://doi.org/10.1378/chest.127.4.1232
  44. US Department of health and human services. The health consequences of involuntary smoking: A report of the surgeon general. Rockville (ML): US department of health and human services, 1986. 363 p. (DHHS publication; no. (CDC) 87-8398)
  45. Cook DG, Strachan DP, Carey IM. Health effects of passive smoking. 9. Parental smoking and spirometric indices in children. Thorax 1998;53:884-93 https://doi.org/10.1136/thx.53.10.884
  46. Young S, Le Souef PN, Geelhoed GC, Stick SM, Turner KJ, Landau LI. The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy. N Engl J Med 1991;324:1168-73
  47. Cook DG, Strachan DP. Parental smoking, bronchial reactivity and peak flow variability in children. Thorax 1998;53:295-301 https://doi.org/10.1136/thx.53.4.295
  48. Dubus JC, Oddoze C, Badier M, Guillot C, Bruguerolle B. Possible interaction between exposure to environmental tobacco smoke and therapy in children with asthma. Clin Sci (Lond) 1998;95:143-9 https://doi.org/10.1042/CS19970301
  49. Menon P, Rando RJ, Stankus RP, Salvaggio JE, Lehrer SB. Passive cigarette smoke-challenge studies: increase in bronchial hyperreactivity. J Allergy Clin Immunol 1992;89:560-6 https://doi.org/10.1016/0091-6749(92)90323-T
  50. Stankus RP, Menon PK, Rando RJ, Glindmeyer H, Salvaggio JE, Lehrer SB. Cigarette smoke-sensitive asthma: challenge studies. J Allergy Clin Immunol 1988;82:331-8 https://doi.org/10.1016/0091-6749(88)90003-6
  51. Min MG, Song DJ, Miller M, Cho JY, McElwain S, Ferguson P, et al. Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice. J Immunol 2007;178:5321-8
  52. Feleszko W, Zawadzka-Krajewska A, Matysiak K, Lewandowska D, Peradzynska J, Dinh QT, et al. Parental tobacco smoking is associated with augmented IL-13 secretion in children with allergic asthma. J Allergy Clin Immunol 2006;117:97-102 https://doi.org/10.1016/j.jaci.2005.09.008
  53. Diaz-Sanchez D, Rumold R, Gong H, Jr. Challenge with environmental tobacco smoke exacerbates allergic airway disease in human beings. J Allergy Clin Immunol 2006;118:441-6 https://doi.org/10.1016/j.jaci.2006.04.047
  54. Seymour BW, Pinkerton KE, Friebertshauser KE, Coffman RL, Gershwin LJ. Second-hand smoke is an adjuvant for T helper-2 responses in a murine model of allergy. J Immunol 1997;159:6169-75
  55. Moerloose KB, Pauwels RA, Joos GF. Short-term cigarette smoke exposure enhances allergic airway inflammation in mice. Am J Respir Crit Care Med 2005;172:168-72 https://doi.org/10.1164/rccm.200409-1174OC
  56. Melgert BN, Postma DS, Geerlings M, Luinge MA, Klok PA, van der Strate BW, et al. Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice. Am J Respir Cell Mol Biol 2004;30:880-5 https://doi.org/10.1165/rcmb.2003-0178OC
  57. Robbins CS, Pouladi MA, Fattouh R, Dawe DE, Vujicic N, Richards CD, et al. Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization. J Immunol 2005;175:2834-42
  58. Rao SP, Sikora L, Hosseinkhani MR, Pinkerton KE, Sriramarao P. Exposure to environmental tobacco smoke induces angiogenesis and leukocyte trafficking in lung microvessels. Exp Lung Res 2009;35:119-35 https://doi.org/10.1080/01902140802449729
  59. Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-200
  60. Elliot J, Vullermin P, Robinson P. Maternal cigarette smoking is associated with increased inner airway wall thickness in children who die from sudden infant death syndrome. Am J Respir Crit Care Med 1998;158:802-6