Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Association Between Gamma-Glutamyltransferase and Hypertension Incidence in Rural Prehypertensive Adults

농촌지역 고혈압 전단계 성인의 혈청 Gamma-Glutamyltransferase와 고혈압 발생률간의 관련성

  • Hwang, Jun-Hyun (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Shin, Ji-Yeon (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Chun, Byung-Yeol (Health Promotion Research Center, Kyungpook National University) ;
  • Lee, Duk-Hee (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Kim, Keon-Yeop (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Park, Wee-Hyun (Department of Internal Medicine, School of Medicine, Kyungpook National University) ;
  • Chae, Shung-Chull (Department of Internal Medicine, School of Medicine, Kyungpook National University)
  • 황준현 (경북대학교 의학전문대학원 예방의학교실) ;
  • 신지연 (경북대학교 의학전문대학원 예방의학교실) ;
  • 천병렬 (경북대학교 건강증진연구소) ;
  • 이덕희 (경북대학교 의학전문대학원 예방의학교실) ;
  • 김건엽 (경북대학교 의학전문대학원 예방의학교실) ;
  • 박의현 (경북대학교 의학전문대학원 내과학교실) ;
  • 채성철 (경북대학교 의학전문대학원 내과학교실)
  • Published : 2010.01.31
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Abstract

Objectives: Prehypertension is associated with a higher risk of developing hypertension compared with normotension. Yet, factors predicting the development of hypertension among prehypertensive people are ill-understood. This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults. Methods: Study subjects were 293 prehypertensive persons >30-years-of-age who participated in a community-based health survey in 2003 and who were followed up in 2008. Sex-specific quartiles of baseline serum GGT were used to examine association with 5-year hypertension incidence. Results: Baseline serum GGT within normal range predicted the risk of developing hypertension for 5 years only in prehypertensive women. Adjusted relative risks were 1.0, 3.7, 3.6, and 6.0 according to quartiles of baseline serum GGT (P for trend <0.01). This pattern was similarly observed in non-drinkers. However, serum GGT was not associated with incident hypertension in men. Different from serum GGT, baseline serum alanine aminotransferase, another well-known liver enzyme, did not predict the risk of incident hypertension in both genders. Conclusions: Even though baseline serum GGT within normal range strongly predicted the future risk of hypertension, it was observed only in women, Although underlying mechanisms of this association are currently unclear, serum GGT can be used to select a high risk group of hypertension in prehypertensive women.

Keywords

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