Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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Two Bayesian methods for sample size determination in clinical trials

  • Kwak, Sang-Gyu (Department of Statistics, Kyungpook National University) ;
  • Kim, Dal-Ho (Department of Statistics, Kyungpook National University) ;
  • Shin, Im-Hee (Department of Medical Statistics, School of Medicine, Catholic University of Daegu) ;
  • Kim, Ho-Gak (Division of Gastroenterology, Department of Internal Medicinel, School of Medicine, Catholic University of Daeg) ;
  • Kim, Sang-Gyung (Department of Laboratory Medicine, School of Medicine, Catholic University of Daegu)
  • Received : 2010.10.23
  • Accepted : 2010.11.15
  • Published : 2010.11.30
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Abstract

Sample size determination is very important part in clinical trials because it influences the time and the cost of the experimental studies. In this article, we consider the Bayesian methods for sample size determination based on hypothesis testing. Specifically we compare the usual Bayesian method using Bayes factor with the decision theoretic method using Bayesian reference criterion in mean difference problem for the normal case with known variances. We illustrate two procedures numerically as well as graphically.

Keywords

References

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