Food Science of Animal Resources (한국축산식품학회지)

Korean Society for Food Science of Animal Resources (한국축산식품학회)
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Bioactive Conjugated Linoleic Acid (CLA) in Milk

  • Kee, Jun-Ill (Department of Food Science and Technology, Sejong University) ;
  • Ganesan, Palanivel (Department of Food Science and Technology, Sejong University) ;
  • Kwak, Hae-Soo (Department of Food Science and Technology, Sejong University)
  • Received : 2010.11.23
  • Accepted : 2010.12.22
  • Published : 2010.12.31
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Abstract

Conjugated linoleic acid (CLA) isomers are found naturally in foods, such as milk, milk products, beef and others, from biohydrogenation of vegetable oils. They are heterogenous group of isomers of linoleic acid in the family of polyunsaturated fatty acids. Among the isomers of linoleic acid cis9, trans11- CLA (c9, t11-CLA) and trans10, cis12- CLA (t10, c12-CLA) are found to be biologically active isomers. These biologically active isomers either individual or combined found to be health beneficial in various diseases, such as cancer, diabetes, obesity, and atherosclerosis, conclusive participation in physiological processes are necessary. This review focused on the current study of CLA in prevention of disease, such as cancer, diabetes and atherosclerosis, and their effective function in body fat reduction, improvement of bone and muscle mass at a cellular, clinical and systematic level.

Keywords

References

  1. Akahoshi, A., Koba, K., Ichinose, F., Kaneko, M., Shimoda, A., Nonaka, K., Iwata, T., Yamauchi, Y., Tsutsumi, K., and Sugano, M. (2004) Dietary protein modulates the effect of CLA on lipid metabolism in rats. Lipids 39, 25-30. https://doi.org/10.1007/s11745-004-1197-3
  2. Andreoli, M. F., Gonzalez, M. A., Martinelli, M. I., Mocchiutti, N. O., and Bernal, C. A. (2009) Effects of dietary conjugated linoleic acid at high-fat levels on triacylglycerol regulation in mice. Nutrition 25, 445-452. https://doi.org/10.1016/j.nut.2008.10.015
  3. Aro, A., Mannisto, S., Salminen, I., Ovaskainen, M. L., Kataja, V., and Uusitupa, M. (2000) Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. Nutr. Cancer 38, 151-157. https://doi.org/10.1207/S15327914NC382_2
  4. Badr El-Din, N. K. and Omaye, S. T. (2007) Concentration dependent anti-oxidant activities of conjugated linoleic acid and $\alpha$-tocopherol in corn oil. J. Sci. Food Agric. 83, 2315-2320.
  5. Bassaganya-Riera, J. and Hontecillas, R. (2006) CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin. Nutr 25, 454-465. https://doi.org/10.1016/j.clnu.2005.12.008
  6. Belury, M. A. (2003) Conjugated linoleic acids in type 2 diabetes mellitus: implications and potential mechanisms. In: Advances in Conjugated Linoleic Acid Research, Sebedio, J., Christie, W.W., Adlof, R. (eds.), AOCS, Champaign, IL, USA, Vol. 2, pp. 302-315.
  7. Benjamin, S. and Spener, F. (2009) Conjugated linoleic acid as functional food: an insight into their health benefits. Nutr. Metab. 6, 36-48. https://doi.org/10.1186/1743-7075-6-36
  8. Benjamin, S., Hanhoff, T., Borchers, T., and Spener, F. (2005) A molecular test system for the screening of human PPAR transactivation by conjugated linoleic acid isomers and their precursor fatty acids. Eur. J. Lipid Sci. Technol. 107, 706-715. https://doi.org/10.1002/ejlt.200401041
  9. Bhattacharya, A., Banu, J., Rahman, M., Causey, J., and Fernandes, G. (2006) Biological effects of conjugated linoleic acids in health and disease. J. Nutr. Biochem. 17, 789-810. https://doi.org/10.1016/j.jnutbio.2006.02.009
  10. Bocca, C., Bozzo, F., Francica, S., Colombatto, S., and Miglietta, A. (2007) Involvement of PPAR gamma and Ecadherin/beta-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells. Int. J. Cancer 121, 248-256. https://doi.org/10.1002/ijc.22646
  11. Brasil (2007) Ministerio da Saude. Agencia Nacional de Vigilancia Sanitaria - ANVISA. Resolucao $n^{\circ}$ 833, 28 de marco de. Resolve Determinar a apreensao, em todo territorio nacional, de todos os lotes do produto acido linoleico conjugado - CLA, por nao possuir registro no Ministerio da Saude. Diario Oficial da Uniao, Brasilia, DF, 29 mar. 2007. Secao 1, p. 68.
  12. Carvalho, E. B. T., Melo, I. L. P., and Mancini-Filho, J. (2010) Chemical and physiological aspects of isomers of conjugated fatty acids. Ciencia e Tecnologia de Alimento. 30, 295-307.
  13. Choi, J. S., Jung, M. H., Park, H. S., and Song, J. (2004) Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition 20, 1008-1017. https://doi.org/10.1016/j.nut.2004.08.009
  14. Collomb, M., Schmid, A., Sieber, R., Wechsler D., and Ryhanen, E. L. (2006) Conjugated linoleic acid in milk fat: Variation and physiological effects. Int. Dairy J. 16, 1347-1361. https://doi.org/10.1016/j.idairyj.2006.06.021
  15. Collomb, M., Sieber, R., and Butikofer, U. (2004) CLA isomers in milk fat from cows fed diets with high levels of unsaturated fatty acids. Lipids. 39, 355-364. https://doi.org/10.1007/s11745-004-1239-x
  16. Doyle, L., Jewell, C., Mullen, A., Nugent, A. P., Roche, H. M., and Cashman, K. D. (2005) Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men. Eur. J. Clin. Nutr. 59, 432-440. https://doi.org/10.1038/sj.ejcn.1602093
  17. Fagali, N. and Catala, A. (2008) Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH techniques. Biophys. Chem.13, 56-62.
  18. Halade, G. V., Rahman, M. M., and Fernandes, G. (2010) Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6 J mice. J. Nutr. Biochem. 21, 332-337. https://doi.org/10.1016/j.jnutbio.2009.01.006
  19. Hur, S. J. and Park, Y. (2007) Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis. Eur. J. Pharmacol. 568, 16-24. https://doi.org/10.1016/j.ejphar.2007.04.056
  20. Ip, C., Dong, Y., Ip, M. M., Banni, S., Carta, G., Angioni, E., Murru, E., Spada, S., Melis, M. P., and Saebo, A. (2002) Conjugated linoleic acid isomers and mammary cancer prevention. Nutr. Cancer 43, 52-58. https://doi.org/10.1207/S15327914NC431_6
  21. Jones, A., Deb, R., Torsney, E., Howe, F., Dunkley, M., Gnaneswaran, Y., Gaze, D., Nasr, H., Loftus, I. M., Thompson, M. M., and Cockerill, G. W. (2009) Rosiglitazone reduces the development and rupture of experimental aortic aneurysms. Circulation 119, 3125-3132. https://doi.org/10.1161/CIRCULATIONAHA.109.852467
  22. Kelley, N. S., Hubbard, N. E., and Erickson, K. L. (2007) Conjugated linoleic acid isomers and cancer. J. Nutr. 137, 2599-2607.
  23. Khanal, R. C. (2004) Potential health benefits of conjugated linoleic acid (CLA): A review. Asian-Austral. J. Anim. Sci. 17, 1315-1328. https://doi.org/10.5713/ajas.2004.1315
  24. Kim, H. K., Kim, S. R., Ahn, J. Y., Cho, I. J., Yoon, C. S., and Ha, T. Y. (2005) Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. J. Nutr. Sci. Vitaminol. (Tokyo). 51, 8-15. https://doi.org/10.3177/jnsv.51.8
  25. Knekt, P., Jarvinen, R., Seppanen, R., Pukkala, E., and Aromaa. A. (1996) Intake of dairy products and the risk of breast cancer. Br. J. Cancer 73, 687-691. https://doi.org/10.1038/bjc.1996.119
  26. Kraft, J., Collomb, M., Mockel, P., Sieber, R., and Jahreis, G. (2003) Differences in CLA isomer distribution of cows' milk lipids. Lipids 38, 657-664. https://doi.org/10.1007/s11745-003-1111-z
  27. Larsen, T. M., Toubro, S., and Astrup, A. (2003) Efficacy and safety of dietary supplements containing conjugated linoleic acid (CLA) for the treatment of obesity-evidence from animal and human studies. J. Lipid Res. 44, 2234-2241. https://doi.org/10.1194/jlr.R300011-JLR200
  28. Larsson, S. C., Bergkvist, L., and Wolk, A. (2005) High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort. Am. J. Clin. Nutr. 82, 894-900.
  29. Lee, K. W., Lee, H. J., Cho, H. Y., and Kim, Y. J. (2005) Role of the conjugated linoleic acid in the prevention of cancer. Crit .Rev. Food Sci. Nutr. 45, 135-144. https://doi.org/10.1080/10408690490911800
  30. Lee, Y. and Vanden Heuvel, J. P. (2010) Inhibition of macrophage adhesion activity by 9trans,11trans-conjugated linoleic acid. Inhibition of macrophage adhesion activity by 9trans, 11trans-conjugated linoleic acid. J. Nutr. Biochem. 21, 490-497. https://doi.org/10.1016/j.jnutbio.2009.02.005
  31. Martin, J. C. and Valeille, K. (2002) Conjugated linoleic acids: all the same or to everyone its own function? Reprod. Nutr. Dev. 42, 525-536. https://doi.org/10.1051/rnd:2002042
  32. McCann, S. E., Ip, C., Ip, M. M., McGuire, M. K., Muti, P., Edge, S. B., Trevisan, M., and Freudenheim, J. L. (2004) Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study). Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research. Cosponsored by the American Society of Preventive Oncology 13, 1480-1484.
  33. Moloney, F., Toomey, S., Noone, E., Nugent, A., Allan, B., Loscher, C. E., and Roche, H. M. (2007) Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56, 574-582. https://doi.org/10.2337/db06-0384
  34. Nakamura, Y. K., Flintoff-Dye, N., and Omaye, S. T. (2008) Conjugated linoleic acid modulation of risk factors associated with atherosclerosis. Nutr. Metab. (London). 21, 5-22.
  35. Park, Y. and Pariza, M. W. (2007) Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Res. Int. 40, 311-323. https://doi.org/10.1016/j.foodres.2006.11.002
  36. Park, Y., Albright, K. J., Storkson, J. M. Liu, W., and Pariza, M. W. (2007) Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model. J. Food Sci. 72, 612-617. https://doi.org/10.1111/j.1750-3841.2007.00477.x
  37. Park, Y., Pariza, M. W., and Park, Y. (2008) Co-supplementation of dietary calcium and conjugated linoleic Acid (CLA) improves bone mass in mice. J. Food Sci. 73, 556-560. https://doi.org/10.1111/j.1750-3841.2008.00861.x
  38. Park, Y., Storkson, J. M., Ntambi, J. M., Cook, M. E., Sih, C. J., and Pariza, M. W. (2000) Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta. 1486, 285-292. https://doi.org/10.1016/S1388-1981(00)00074-3
  39. Park, Y. (2009) Bioactive components in milk and Dairy products.1st ed, John Wiley & Son Pub., Iowa, p. 426.
  40. Parodi P. W. (2003) Anti-cancer agents in milk fat. Aust. J. Dairy Technol. 58, 114-118.
  41. Poirier, H., Shapiro, J. S., Kim, R. J., and Lazar, M. A. (2006) Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 55, 1634-1641. https://doi.org/10.2337/db06-0036
  42. Rahman, M. M., Halade, G. V., El Jamali A., and Fernandes, G. (2009) Conjugated linoleic acid (CLA) prevents age-associated skeletal muscle loss. Biochem. Biophys. Res. Commun. 383, 513-518. https://doi.org/10.1016/j.bbrc.2009.04.071
  43. Reynolds, C. M. and Roche, H. M. (2010) Conjugated linoleic acid and inflammatory cell signaling. Prostaglandins Leukot. Essent Fatty Acids 82, 199-204. https://doi.org/10.1016/j.plefa.2010.02.021
  44. Reynolds, C. M., Loscher, C. E., Moloney, A. P., and Roche, H. M. (2008) Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2. Br. J. Nutr. 100, 13-17.
  45. Ringseis, R., Muller, A., Herter, C., Gahler, S., Steinhart, H., and Eder, K. (2006) CLA isomers inhibit TNF alpha-induced eicosanoid release from human vascular smooth muscle cells via a PPAR-gamma ligand- like action. Biochim. Biophys. Acta 1760, 290-300. https://doi.org/10.1016/j.bbagen.2005.12.002
  46. Rissanen, H., Knekt, P., Jarvinen, R., Salminen, I., and Hakulinen, T. (2003) Serum fatty acids and breast cancer incidence. Nutr. Cancer 45, 168-175. https://doi.org/10.1207/S15327914NC4502_05
  47. Santos-Zago, L. F., Boteho, A. P., and Oliveira, A. C. (2008) Os efeitos do acido linoleico conjugado no metabolismo animal: avanco das pesquisas e perspectivas para o futuro. Revista. de Nutricao. 21, 195-221.
  48. Toomey, S., Harhen, B., Roche, H. M., Fitzgerald, D., and Belton, O. (2006) Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis 187, 40-49. https://doi.org/10.1016/j.atherosclerosis.2005.08.024
  49. Voorrips, L. E., Brants, H. A., Kardinaal, A. F., Hiddink, G., Van den Brandt, J., and Goldbohm, P. A. (2002) Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. Am. J. Clin. Nutr. 76, 873-882.
  50. Wang, H. Y., Qu, P., Lu, S., Liu, M., and Jiang, H. (2005) The effects of TLR4/NF-kappaB activatioin and LOX-1 on monocyte adhesion to endothelium. Zhonghua Xin Xue Guan Bing Za Zhi. 33, 827-831.
  51. Watkins, B. A., Li, Y., Lippman, H. E., and Seifert, M. F. (2004) A test of Ockham's razor: implications of conjugated linoleic acid in bone biology. Am. J. Clin. Nutr. 79, 1175-1185.
  52. Wendel, A. A., Purushotham, A., Liu, L. F., and Belury, M. A. (2008) Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 49, 98-106. https://doi.org/10.1194/jlr.M700195-JLR200
  53. Whigham, L. D., Watras, A. C., and Schoeller, D. A. (2007) Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am. J. Clin. Nutr. 85, 1203-1211.
  54. Wilson, T. A., Nicolosi, R. J., Saati, A., Kotyla, T., and Kritchevsky, D. (2006) Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters. Lipids 41, 41-48. https://doi.org/10.1007/s11745-006-5068-8
  55. Yang, L., Cao, Y., Chen, J. N., and Chen, Z. Y. (2009) Oxidative Stability of conjugated linolenic acids. J. Agric. Food Chem. 57, 4212-4217. https://doi.org/10.1021/jf900657f
  56. Zhou, X. R., Sun, C. H., Liu, J. R., and Zhao, D. (2008) Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm. IGF Res. 18, 361-368. https://doi.org/10.1016/j.ghir.2008.01.001

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