Journal of Oral Medicine and Pain

Korean Academy of Orofacial Pain and Oral Medicine (대한안면통증구강내과학회)
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Malignant Acanthosis Nigricans with Oral Florid Papillomatosis ; A Case Report

구강내 개화성 유두종증을 가진 악성 흑색극세포증의 증례보고

  • Jung, Jae-Kwang (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Shin, Hong-Ihn (Department of Oral Pathology, School of Dentistry, Kyungpook National University) ;
  • Min, Bo-Kyung (Department of Oral Medicine, School of Dentistry, Kyungpook National University)
  • 정재광 (경북대학교 치의학전문대학원 구강내과학교실) ;
  • 신홍인 (경북대학교 치의학전문대학원 구강병리학교실) ;
  • 민보경 (경북대학교 치의학전문대학원 구강내과학교실)
  • Received : 2010.09.12
  • Accepted : 2010.10.15
  • Published : 2010.12.30
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Abstract

Acanthosis nigricans usually has the characteristics that involve the development of darker pigmented patches and thickened skin with velvety texture on the body folds, and papillomatosis on lip and intraoral regions including tongue, gingiva, mucosa, palate. Malignant acanthosis nigricans, a type of acanthosis nigricans, occurs most commonly in association with underlying malignancy and characterically appears with three characteristic mucocutaneous lesion : especially of the lips and eyelids, hyperkeratosis of the palms and soles, the sign of Leser-Trelat. In the present report, the patient had typical clinical and histological findings of oral acanthosis nigricans, as well as past medical history associated with malignant gastric adenocarcinoma.

흑색극세포증은 대개 피부가 접히는 부위에서 짙은 색의 반점과 함께 벨벳양상을 가진 두꺼워진 피부 그리고 혀, 치은, 점막, 구개를 포함하는 구강내 및 입술부위의 유두종증의 특징을 가진다. 그중에서도 악성 흑색극세포증은 기저 암종과 연관되어 발생되며 특징적으로 입술과 눈꺼풀의 개화성 유두종증, 손바닥 및 발바닥의 저명한 과각화증, 레제르-트렐라 증후와 같은 세가지 특징이 나타난다. 본 증례의 환자에서 악성 흑색극세포증의 전형적인 임상적 그리고 조직학적 특징과 함께 악성 위장 선암종의 병력을 가지고 있었다.

Keywords

References

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