DOI QR코드

DOI QR Code

Intracranial Dissemination from Spinal Cord Anaplastic Astrocytoma

  • Jeong, Seong-Man (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Chung, Yong-Gu (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Lee, Jang-Bo (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Shin, Il-Young (Department of Neurosurgery, College of Medicine, Korea University)
  • Published : 2010.01.28

Abstract

We report a case of intracranial dissemination developing approximately 4 months after partial removal of a spinal cord anplastic astrocytoma in a 22-year-old male. He presented with paraplegia on initial admission at a local hospital. Spinal magnetic resonance (MR) images disclosed multiple intramedullary lesions at the T3-11. The tumor was partially removed. The final histologic diagnosis was anaplastic astrocytoma. Four months after the operation, he was admitted with the symptoms of headache and deterioration of consciousness. MR images showed enhanced lesions in the anterior horn of the left lateral ventricle, and septum pellucidum. He underwent computed tomography-guided stereotactic biopsy and histological appearance was consistent with anaplastic astrocytoma. The clinical course indicates that the tumor originated in the spinal cord and extended into the subarachnoid space, first the spinal canal and later intracranial.

Keywords

References

  1. Asano N, Kitamura K, Seo Y, Mukai K, Soga T, Hondo H, et al. : Spinal cord glioblastoma multiforme with intracranial disseminationcase report. Neurol Med Chir (Tokyo) 30 : 489-494, 1990 https://doi.org/10.2176/nmc.30.489
  2. Bell WO, Packer RJ, Seigel KR, Rorke LB, Sutton LN, Bruce DA, et al. : Leptomeningeal spread of intramedullary spinal cord tumors. Report of three cases. J Neurosurg 69 : 295-300, 1988 https://doi.org/10.3171/jns.1988.69.2.0295
  3. Cohen AR, Wisoff JH, Allen JC, Epstein F : Malignant astrocytomas of the spinal cord. J Neurosurg 70 : 50-54, 1989 https://doi.org/10.3171/jns.1989.70.1.0050
  4. Faria MH, Gonçalves BP, do Patrocínio RM, de Moraes-Filho MO, Rabenhorst SH : Expression of Ki-67, topoisomerase IIalpha and c- MYC in astrocytic tumors : correlation with the histopathological grade and proliferative status. Neuropathology 26 : 519-527, 2006 https://doi.org/10.1111/j.1440-1789.2006.00724.x
  5. Johannessen AL, Torp SH : The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas. Pathol Oncol Res 12 : 143-147, 2006 https://doi.org/10.1007/BF02893360
  6. Ogawa Y, Sugawara T, Seki H, Sakuma T : Central neurocytomas with MIB-1 labeling index over 10% showing rapid tumor growth and dissemination. J Neurooncol 79 : 211-216, 2006 https://doi.org/10.1007/s11060-006-9129-x
  7. Saitoh M, Kuwamura K : [Report of a case of intracranial metastases from malignant spinal cord astrocytoma.] Rinsho Hoshasen 34 : 249-252, 1989
  8. Umezu H, Seki Y, Aiba T, Matsuya S : Intracranial seeding following surgery for spinal cord astrocytoma-case report. Neurol Med Chir (Tokyo) 32 : 281-284, 1992 https://doi.org/10.2176/nmc.32.281
  9. Yamashita Y, Kumabe T, Jokura H, Tominaga T, Yoshimoto T : Intracranial dissemination from thoracic spinal cord anaplastic astrocytoma in a patient with idiopathic CD4-positive T lymphocytopenia : a case report. Surg Neurol 56 : 39-41, 2001 https://doi.org/10.1016/S0090-3019(01)00498-0

Cited by

  1. Intracranial metastasis of spinal intramedullary anaplastic astrocytoma vol.6, pp.2, 2011, https://doi.org/10.4103/1793-5482.92179
  2. Intracranial spreading of a spinal anaplastic astrocytoma vol.259, pp.4, 2010, https://doi.org/10.1007/s00415-011-6253-0
  3. Intramedullary Glioblastoma Multiforme of Spine with Intracranial Supratentorial Metastasis: Progressive Disease with a Multifocal Picture vol.13, pp.4, 2010, https://doi.org/10.4103/ajns.ajns_67_17
  4. Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review vol.10, pp.None, 2010, https://doi.org/10.3389/fonc.2020.00099
  5. Intracranial Metastases of Intramedullary Spinal Cord Low-Grade Astrocytoma vol.41, pp.1, 2020, https://doi.org/10.4103/ijmpo.ijmpo_64_18
  6. Invited Commentary: A Framework for the Differential Diagnosis of Benign and Malignant Intramedullary Tumors vol.40, pp.4, 2010, https://doi.org/10.1148/rg.2020200059
  7. Multifocal spinal glioblastoma and leptomeningeal carcinomatosis in an elderly male with hydrocephalus and myelopathy vol.12, pp.None, 2021, https://doi.org/10.25259/sni_985_2021