Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Reemergence of mumps

  • Choi, Kyong-Min (Department of Pediatrics, Kwandong University College of Medicine)
  • Received : 2010.04.08
  • Accepted : 2010.04.15
  • Published : 2010.05.15
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Abstract

The mumps virus is a single-stranded, non-segmented, negative-sense RNA virus belonging to the $Paramyxoviridae$ family. Mumps is characterized by bilateral or unilateral swelling of the parotid gland. Aseptic meningitis is a common complication, and orchitis is also common in adolescents and adult men. Diagnosis is based on clinical findings, but because of high vaccination coverage, clinical findings alone are not sufficient for diagnosis, and laboratory confirmation is needed. Mumps is preventable by vaccination, but despite high vaccination coverage, epidemics occur in several countries, including Korea. Many hypotheses are suggested for these phenomena. In this review, we investigate the reason for the epidemics, optimal methods of diagnosis, and surveillance of immunization status for the prevention of future epidemics.

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References

  1. Peltola H, Davidkin I, Paunio M, Valle M, Leinikki P, Heinonen OP. Mumps and rubella eliminated from Finland. JAMA 2000;284:2643-7. https://doi.org/10.1001/jama.284.20.2643
  2. Ong G, Goh KT, Ma S, Chew SK. Comparative efficacy of Rubini, Jeryl-Lynn and Urabe mumps vaccine in an Asian population. J Infect 2005;51:294-8. https://doi.org/10.1016/j.jinf.2004.10.001
  3. Atrasheuskaya AV, Blatun EM, Kulak MV, Atrasheuskaya A, Karpov IA, Rubin S, et al. Investigation of mumps vaccine failures in Minsk, Belarus, 2001-2003. Vaccine 2007;25:4651-8. https://doi.org/10.1016/j.vaccine.2007.04.020
  4. Cohen C, White JM, Savage EJ, Glynn JR, Choi Y, Andrews N, et al. Vaccine effectiveness estimates, 2004-2005 mumps outbreak, England. Emerg Infect Dis 2007;13:12-7.
  5. Peltola H, Kulkarni PS, Kapre SV, Paunio M, Jadhav SS, Dhere RM. Mumps outbreaks in Canada and the United States: time for new thinking on mumps vaccines. Clin Infect Dis 2007;45:459-66. https://doi.org/10.1086/520028
  6. Rubin S, Qi L, Audet S, Sullivan B, Carbone K, Bellini W, et al. Antibody induced by immunization with the Jeryl Lynn mumps vaccine strain effectively neutralizes a heterologous wild-type mumps virus associated with a large outbreak. J Infect Dis 2008;198:508-15. https://doi.org/10.1086/590115
  7. Mortimer PP. Mumps prophylaxis in the light of a new test for antibody. Br Med J 1978;2:1523-4.
  8. Galazka AM, Robertson SE, Kraigher A. Mumps and mumps vaccine: a global review. Bull World Health Organ 1999;77:3-14.
  9. Dayan GH, Quinlisk MP, Parker AA, Barskey AE, Harris ML, Schwartz JM, et al. Recent resurgence of mumps in the United States. N Engl J Med 2008;358:1580-9. https://doi.org/10.1056/NEJMoa0706589
  10. Stein-Zamir C, Shoob H, Abramson N, Tallen-Gozani E, Sokolov I, Zentner G. Mumps outbreak in Jerusalem affecting mainly male adolescents. Euro Surveill [Internet]. 2009 Dec 17 [cited];14(50):pii=19440. Available from: http://www.eurosurveillance. org/ViewArticle.aspx?ArticleId=19440.
  11. Brockhoff HJ, Mollema L, Sonder GJ, Postema CA, van Binnendijk RS, Kohl RH, et al. Mumps outbreak in a highly vaccinated student population, The Netherlands, 2004. Vaccine 2010;28:2932-6 https://doi.org/10.1016/j.vaccine.2010.02.020
  12. Schwarz NG, Bernard H, Melnic A, Bucov V, Caterinciuc N, An der Heiden M, et al. Mumps outbreak in the Republic of Moldova, 2007- 2008. Pediatr Infect Dis J 2010 Epub ahead of print
  13. Lee JY, Na BK, Kim JH, Lee JS, Park JW, Shin GC, et al. Regional outbreak of mumps due to genotype H in Korea in 1999. J Med Virol 2004;73:85-90. https://doi.org/10.1002/jmv.20047
  14. Park DW, Nam M-H, Kim JY, Kim HJ, Sohn JW, Cho Y, et al. Mumps outbreak in a highly vaccinated school population: assessment of secondary vaccine failure using IgG avidity measurements. Vaccine 2007;25:4665-70. https://doi.org/10.1016/j.vaccine.2007.04.013
  15. Mumps epidemic--United kingdom, 2004-2005. MMWR Morb Mortal Wkly Rep 2006;55:173-5.
  16. Brief report: update: mumps activity--United States, January 1-October 7, 2006. MMWR Morb Mortal Wkly Rep 2006;55:1152-3.
  17. Hviid A, Rubin S, Muhlemann K. Mumps. Lancet 2008;371:932-44. https://doi.org/10.1016/S0140-6736(08)60419-5
  18. Barskey AE, Glasser JW, LeBaron CW. Mumps resurgences in the United States: A historical perspective on unexpected elements. Vaccine 2009;27:6186-95. https://doi.org/10.1016/j.vaccine.2009.06.109
  19. Update: mumps outbreak - New York and New Jersey, June 2009- January 2010. MMWR Morb Mortal Wkly Rep 2010;59:125-9.
  20. Bartak V. Sperm count, morphology and motility after unilateral mumps orchitis. J Reprod Fertil 1973;32:491-4. https://doi.org/10.1530/jrf.0.0320491
  21. Beard CM, Benson RC, Jr., Kelalis PP, Elveback LR, Kurland LT. The incidence and outcome of mumps orchitis in Rochester, Minnesota, 1935 to 1974. Mayo Clin Proc 1977;52:3-7.
  22. A retrospective survey of the complications of mumps. J R Coll Gen Pract 1974;24:552-6.
  23. Utz JP, Houk VN, Alling DW. Clinical and laboratory studies of mumps. N Engl J Med 1964;270:1283-6. https://doi.org/10.1056/NEJM196406112702404
  24. Cochi SL, Preblud SR, Orenstein WA. Perspectives on the relative resurgence of mumps in the United States. Am J Dis Child 1988;142:499-507.
  25. Sever J, White LR. Intrauterine viral infections. Annu Rev Med 1968;19:471-86. https://doi.org/10.1146/annurev.me.19.020168.002351
  26. Siegel M. Congenital malformations following chickenpox, measles, mumps, and hepatitis. Results of a cohort study. JAMA 1973;226:1521- 4. https://doi.org/10.1001/jama.226.13.1521
  27. Gans H, Yasukawa L, Rinki M, DeHovitz R, Forghani B, Beeler J, et al. Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months. J Infect Dis 2001;184:817-26. https://doi.org/10.1086/323346
  28. Jokinen S, Osterlund P, Julkunen I, Davidkin I. Cellular immunity to mumps virus in young adults 21 years after measles-mumps-rubella vaccination. J Infect Dis 2007;196:861-7. https://doi.org/10.1086/521029
  29. Guy RJ, Andrews RM, Kelly HA, Leydon JA, Riddell MA, Lambert SB, et al. Mumps and rubella: a year of enhanced surveillance and laboratory testing. Epidemiol Infect 2004;132:391-8. https://doi.org/10.1017/S0950268804001955
  30. Davidkin I, Jokinen S, Paananen A, Leinikki P, Peltola H. Etiology of Mumps-like Illnesses in children and adolescents vaccinated for measles, mumps, and rubella. J Infect Dis 2005;191:719-23. https://doi.org/10.1086/427338
  31. Lane TM, Hines J. The management of mumps orchitis. BJU Int 2006;97:1-2.
  32. Erpenbach KH. Systemic treatment with interferon-alpha 2B: an effective method to prevent sterility after bilateral mumps orchitis. J Urol 1991;146:54-6. https://doi.org/10.1016/S0022-5347(17)37713-3
  33. Buyukavci M, Yildirim ZK, Tan H. High-dose IVIG therapy in a child with idiopathic thrombocytopenic purpura associated with mumps. J Pediatr Hematol Oncol 2005;27:56-7.
  34. Sonmez FM, Odemis E, Ahmetoglu A, Ayvaz A. Brainstem encephalitis and acute disseminated encephalomyelitis following mumps. Pediatr Neurol 2004;30:132-4. https://doi.org/10.1016/j.pediatrneurol.2003.09.004
  35. Bajaj NP, Rose P, Clifford-Jones R, Hughes PJ. Acute transverse myelitis and Guillain- Barré overlap syndrome with serological evidence for mumps viraemia. Acta Neurol Scand 2001;104:239-42. https://doi.org/10.1034/j.1600-0404.2001.00340.x
  36. Nokes DJ, Anderson RM. Measles, mumps, and rubella vaccine: what coverage to block transmission? Lancet 1988;2:1374.
  37. World Health Organization. Mumps virus vaccines. Wkly Epidemiol Rec 2001;76:346-55.
  38. Hilleman MR, Weibel RE, Buynak EB, Stokes J, Jr., Whitman JE, Jr. Live attenuated mumps-virus vaccine. IV. Protective efficacy as measured in a field evaluation. N Engl J Med 1967;276:252-8. https://doi.org/10.1056/NEJM196702022760502
  39. Sugg WC, Finger JA, Levine RH, Pagano JS. Field evaluation of live virus mumps vaccine. J Pediatr 1968;72:461-6. https://doi.org/10.1016/S0022-3476(68)80334-8
  40. Miller E, Hill A, Morgan-Capner P, Forsey T, Rush M. Antibodies to measles, mumps and rubella in UK children 4 years after vaccination with different MMR vaccines. Vaccine 1995;13:799-802. https://doi.org/10.1016/0264-410X(94)00086-3
  41. Davidkin I, Valle M, Julkunen I. Persistence of anti-mumps virus antibodies after a two-dose MMR vaccination. A nine-year follow-up. Vaccine 1995;13:1617-22. https://doi.org/10.1016/0264-410X(95)00064-8
  42. Harling R, White JM, Ramsay ME, Macsween KF, Bosch Cvd. The effectiveness of the mumps component of the MMR vaccine: a case control study. Vaccine 2005;23:4070-4. https://doi.org/10.1016/j.vaccine.2004.10.020
  43. Narita M, Matsuzono Y, Takekoshi Y, Yamada S, Itakura O, Kubota M, et al. Analysis of mumps vaccine failure by means of avidity testing for mumps virus-specific immunoglobulin G. Clin Diagn Lab Immunol 1998;5:799-803.

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