Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Multimodal neuroimaging in presurgical evaluation of childhood epilepsy

  • Jung, Da-Eun (Department of Pediatrics, Ajou University School of Medicine) ;
  • Lee, Joon-Soo (Department of Pediatrics, Pediatric Epilepsy Clinic, Severance Children's Hospital, Brain Research Institute, Yonsei University College of Medicine)
  • Received : 2010.06.05
  • Accepted : 2010.07.15
  • Published : 2010.08.15
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Abstract

In pre-surgical evaluation of pediatric epilepsy, the combined use of multiple imaging modalities for precise localization of the epileptogenic focus is a worthwhile endeavor. Advanced neuroimaging by high field Magnetic resonance imaging (MRI), diffusion tensor images, and MR spectroscopy have the potential to identify subtle lesions. $^{18}F$-FDG positron emission tomography and single photon emission tomography provide visualization of metabolic alterations of the brain in the ictal and interictal states. These techniques may have localizing value for patients which exhibit normal MRI scans. Functional MRI is helpful for non-invasively identifying areas of eloquent cortex. These advances are improving our ability to noninvasively detect epileptogenic foci which have gone undetected in the past and whose accurate localization is crucial for a favorable outcome following surgical resection.

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References

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