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Effects of Isoflurane Anesthesia on Post-Anesthetic Sleep-Wake Architectures in Rats

  • Jang, Hwan-Soo (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Jung, Ji-Young (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Maan-Gee (Department of Pharmacology, School of Medicine, Kyungpook National University)
  • Received : 2010.08.09
  • Accepted : 2010.09.24
  • Published : 2010.10.31

Abstract

The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct restorative effect. Little is known about the effects of isoflurane anesthesia on sleep homeostasis. We investigated whether 1) isoflurane anesthesia could provide a sleep-like process, and 2) the depth of anesthesia could differently affect the post-anesthesia sleep response. Nine rats were treated for 2 hours with $ad$ $libitum$ sleep (Control), sleep deprivation (SD), and isoflurane anesthesia with delta-wave- predominant state (ISO-1) or burst suppression pattern-predominant state (ISO-2) with at least a 1-week interval. Electroencephalogram and electromyogram were recorded and sleep-wake architecture was evaluated for 4 hours after each treatment. In the post-treatment period, the duration of transition to slow-wave-sleep decreased but slow wave sleep (SWS) increased in the SD group, but no sleep stages were significantly changed in ISO-1 and ISO-2 groups compared to Control. Different levels of anesthesia did not significantly affect the post-anesthesia sleep responses, but the deep level of anesthesia significantly delayed the latency to sleep compared to Control. The present results indicate that a natural sleep-like process likely occurs during isoflurane anesthesia and that the post-anesthesia sleep response occurs irrespective to the level of anesthesia.

Keywords

References

  1. Tung A, Mendelson WB. Anesthesia and sleep. Sleep Med Rev. 2004;8:213-225. https://doi.org/10.1016/j.smrv.2004.01.003
  2. Tung A, Bergmann BM, Herrera S, Cao D, Mendelson WB. Recovery from sleep deprivation occurs during propofol anesthesia. Anesthesiology. 2004;100:1419-1426. https://doi.org/10.1097/00000542-200406000-00014
  3. Tung A, Lynch JP, Mendelson WB. Prolonged sedation with propofol in the rat does not result in sleep deprivation. Anesth Analg. 2001;92:1232-1236.
  4. Tung A, Szafran MJ, Bluhm B, Mendelson WB. Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane. Anesthesiology. 2002;97:906-911. https://doi.org/10.1097/00000542-200210000-00024
  5. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008;508:648-662. https://doi.org/10.1002/cne.21685
  6. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003;98:428-436. https://doi.org/10.1097/00000542-200302000-00024
  7. Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M. An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A. 2008;105:1309-1314. https://doi.org/10.1073/pnas.0707146105
  8. Cooper AB, Thornley KS, Young GB, Slutsky AS, Stewart TE, Hanly PJ. Sleep in critically ill patients requiring mechanical ventilation. Chest. 2000;117:809-818. https://doi.org/10.1378/chest.117.3.809
  9. Chen HI, Tang YR. Sleep loss impairs inspiratory muscle endurance. Am Rev Respir Dis. 1989;140:907-909. https://doi.org/10.1164/ajrccm/140.4.907
  10. Irwin M. Effects of sleep and sleep loss on immunity and cytokines. Brain Behav Immun. 2002;16:503-512. https://doi.org/10.1016/S0889-1591(02)00003-X
  11. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999;354:1435-1439. https://doi.org/10.1016/S0140-6736(99)01376-8
  12. Sleigh JW, Andrzejowski J, Steyn-Ross A, Steyn-Ross M. The bispectral index: a measure of depth of sleep? Anesth Analg. 1999;88:659-661. https://doi.org/10.1213/00000539-199903000-00035
  13. Tung A, Lynch JP, Roizen MF. Use of the BIS monitor to detect onset of naturally occurring sleep. J Clin Monit Comput. 2002;17:37-42. https://doi.org/10.1023/A:1015404803637
  14. Maloney KJ, Mainville L, Jones BE. c-Fos expression in dopaminergic and GABAergic neurons of the ventral mesencephalic tegmentum after paradoxical sleep deprivation and recovery. Eur J Neurosci. 2002;15:774-778. https://doi.org/10.1046/j.1460-9568.2002.01907.x
  15. Sapin E, Lapray D, Berod A, Goutagny R, Leger L, Ravassard P, Clement O, Hanriot L, Fort P, Luppi PH. Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep. PLoS ONE. 2009;4:e4272. https://doi.org/10.1371/journal.pone.0004272
  16. Jang HS, Kim JY, Kim SH, Lee MG. Role of dopamine receptors on electroencephalographic changes produced by repetitive apomorphine treatments in rats. Korean J Physiol Pharmacol. 2009;13:147-151. https://doi.org/10.4196/kjpp.2009.13.3.147
  17. Wisor JP, Edgar DM, Yesavage J, Ryan HS, McCormick CM, Lapustea N, Murphy GM Jr. Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission. Neuroscience. 2005;131:375-385. https://doi.org/10.1016/j.neuroscience.2004.11.018
  18. Borbely AA, Tobler I, Hanagasioglu M. Effect of sleep deprivation on sleep and EEG power spectra in the rat. Behav Brain Res. 1984;14:171-182. https://doi.org/10.1016/0166-4328(84)90186-4
  19. Knill RL, Moote CA, Skinner MI, Rose EA. Anesthesia with abdominal surgery leads to intense REM sleep during the first postoperative week. Anesthesiology. 1990;73:52-61. https://doi.org/10.1097/00000542-199007000-00009
  20. Moote CA, Knill RL. Isoflurane anesthesia causes a transient alteration in nocturnal sleep. Anesthesiology. 1988;69:327-331. https://doi.org/10.1097/00000542-198809000-00007
  21. Kavey NB, Ahshuler KZ. Sleep in herniorrhaphy patients. Am J Surg. 1979;138:683-687.
  22. Takahashi S, Kushikata T, Matsuki A. Effects of isoflurane and ketamine on sleep in rabbits. Psychiatry Clin Neurosci. 2001;55:239-240. https://doi.org/10.1046/j.1440-1819.2001.00840.x

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