Changes of the Preoperative and Postoperative Nutritional Statuses in Patients with Gastric Cancer and Assessment of the Nutritional Factors That Are Correlated with Short-Term Postoperative Complications

위암 환자에서 수술 전후의 영양지표의 변화와 수술 후 단기간 합병증과의 연관성

  • Oh, Cheong-Ah (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Dae-Hoon (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Oh, Seung-Jong (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, Min-Gew (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Noh, Jae-Hyung (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sohn, Tae-Sung (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Sung (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Bae, Jae-Moon (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 오정아 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 김대훈 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 오승종 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 최민규 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 노재형 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 손태성 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 김성 (성균관대학교 의과대학 삼성서울병원 외과학교실) ;
  • 배재문 (성균관대학교 의과대학 삼성서울병원 외과학교실)
  • Received : 2009.12.31
  • Accepted : 2010.03.30
  • Published : 2010.03.30

Abstract

Purpose: The aim of this study was to evaluate the preoperative and postoperative nutritional statuses of patients with gastric cancer and to investigate the nutritional factors that are correlated with perioperative complications. Materials and Methods: From January 2008 to Jun 2008, 669 patients who underwent curative gastrectomy were enrolled in a retrospective study. To evaluate the changes of their nutritional status preoperatively and postoperatively, we measured the total lymphocyte count, the serum albumin, the body weight change and the BMI. The nutritional factors correlated with short-term postoperative complications were analyzed. Results: The total lymphocyte count and serum albumin decreased from the first preoperative day to the $5^{th}$ day after operation, but they tended to increase and approach the normal range 6 months after operation. The only factor correlated with the short-term postoperative complications (defined as the ones that occurred for 30 days) was the serum albumin checked on the $5^{th}$ day after operation. Conclusion: Low serum albumin on the $5^{th}$ day after operation was correlated with postoperative short-term complications. Serum albumin can be the preoperative statistical parameter that can predict the occurrence of postoperative complications.

목적: 위 절제술을 받은 위암 환자에서 수술 전후의 영양상태를 손쉽게 시행할 수 있는 간단한 임상적 자료로 변화를 살펴 보고 이들과 수술 후 단기간의 합병증과의 상관관계를 밝히고자 하였다. 대상 및 방법: 2008년 1월부터 2008년 6월까지 위암으로 위 절제술을 시행 받은 환자 669명을 대상으로 이들의 의무기록을 후향적으로 고찰하였다. 환자의 영양 상태를 평가하기 위해 수술 전과 수술 5일 후, 수술 6개월 후의 총 림프구수(TLC, cells/$mm^3$), 혈중 알부민(g/dl), 체중(kg), 체질량 지수(BMI, kg/$m^2$)를 측정하였다. 또한 이들 인자들과 단기간 합병증 발생과의 상관관계를 분석하였다. 결과: TLC와 혈중 알부민은 수술 전에 비해, 수술 5일 후에는 전반적으로 감소되었다가 수술 6개월 후에는 다시 회복하는 추세를 보였다. 6개월 후 환자의 영향 상태에 미치는 요인을 살펴보면, 진행성 위암에서 수술 6개월 후 TLC, 혈중 알부민이 더 낮은 경향을 보였다. 위전절제술 후에 6개월 후의 혈중 알부민과 BMI가 더 낮아지는 경향을 보였다. 보조적 치료를 한 군의 6개월 뒤의 TLC가 더 낮은 경향을 보였고, 체중 감소 비율도 더 컸다. 단기간 합병증 발생과의 상관관계를 갖는 영양 인자는 수술 후 5일째 혈중 알부민과 수술 전과 수술 후 5일째의 혈중 알부민 변화량이었다. 결론: TLC와 혈중 알부민은 수술 5후에는 유의하게 감소 되었다가 수술 6개월 후에는 회복 추세를 보였다. 수술 후 5일째의 혈중 알부민 저하가 합병증과 관련 있는 요소로서, 이환율에 대한 좋은 예측도를 나타내는 지표였다.

Keywords

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