Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Resveratrol Impaired the Morphological Transition of Candida albicans Under Various Hyphae-Inducing Conditions

  • Okamoto-Shibayama, Kazuko (Department of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College) ;
  • Sato, Yutaka (Department of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College) ;
  • Azuma, Toshifumi (Department of Biochemistry and Oral Health Science Center HRC7, Tokyo Dental College)
  • Received : 2009.11.11
  • Accepted : 2010.01.27
  • Published : 2010.05.28
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Abstract

The ability of the human fungal pathogen Candida albicans to undergo the morphological transition from a single yeast form to pseudohyphal and hyphal forms in response to various conditions is known to be important for its virulence. Many studies have shown the pharmacological effects of resveratrol, a phytoalexin polyphenolic compound. In this study, we investigated the antifungal activity of resveratrol against C. albicans. Both yeast-form and mycelial growth of C. albicans were inhibited by resveratrol. In addition, normal filamentation of C. albicans was affected and yeast-to-hypha transition under serum-, pH-, and nutrient-induced hyphal growth conditions was impaired by resveratrol.

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References

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