Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Hydroxyhibiscone A, a Novel Human Neutrophil Elastase Inhibitor from Hibiscus syriacus

  • Ryoo, In-Ja (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yun, Bong-Sik (College of Environmental and Bioresource Sciences, Chunbuk National University) ;
  • Lee, In-Kyoung (College of Environmental and Bioresource Sciences, Chunbuk National University) ;
  • Kim, Young-Hee (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Ik-Soo (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ahn, Jong-Seok (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Yoo, Ick-Dong (Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology)
  • Received : 2010.04.19
  • Accepted : 2010.05.27
  • Published : 2010.08.28
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Abstract

In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with $IC_{50}$ values of 5.2 and 4.6 ${\mu}M$, respectively.

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References

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