The Wound Healing Effect of PDRN(polydeoxyribonucleotide) Material on Full Thickness Skin Defect in the Mouse

흰 쥐의 전층피부 결손에 대한 PDRN (polydeoxyribonucleotide) 제재의 창상치유 효과

  • Kim, Yo-Han (Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Lee, Jong-Hoon (Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Min, Kyung-Hee (Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Hong, Sung-Hee (Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Lee, Won-Mi (Department of Pathology, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Jun, Jin-Hyun (Department of Bio-Medical Laboratory Science, College of Health Science, Eulji University)
  • 김요한 (을지대학교 의과대학 을지병원 성형외과학교실) ;
  • 이종훈 (을지대학교 의과대학 을지병원 성형외과학교실) ;
  • 민경희 (을지대학교 의과대학 을지병원 성형외과학교실) ;
  • 홍성희 (을지대학교 의과대학 을지병원 성형외과학교실) ;
  • 이원미 (을지대학교 의과대학 을지병원 병리학과교실) ;
  • 전진현 (을지대학교 보건과학대학 임상병리학과)
  • Received : 2009.11.26
  • Accepted : 2010.03.23
  • Published : 2010.05.10


Purpose: Many topical agents had been used for burn or wound treatment. An awareness of topical agents on various aspects of wound healing permits the clinician to choose the most appropriate material to advantageously control the wound process and final results. Although polydeoxyribonucleotide (PDRN) was used as a tissue repair stimulating agent in a number of human diseases, such as ulcers and burns, its wound healing effects were largely unreported. We aimed to compare the woundhealing effects of PDRN and common dressing materials on full-thickness skin defect in the mouse. Methods: Full-thickness skin defects were made on the back of mice (N=60). The mice were divided into the following 4 groups according to the dressing used for the wounds: group O (Polydeoxyribonucleotide cream), group I (Polydeoxyribonucleotide solution), group M (Medifoam$^{(R)}$), and group G (dry gauze, control group). We analyzed the gross findings, wound sizes and histological findings for the groups. Results: The rate of wound size was decreased in order of group I, group O, group M and group G. The histological findings revealed that the I group showed more reepithelialization and granulation tissue formation and less inflammatory cell infiltration than the other materials. The grade score of wound healing was increased in order of group I, group O, group M and group G. Conclusion: PDRN applicated wound dressings can be used for treating a full-thickness skin defect wounds. Considering its superior efficacy in comparison to the efficacies of other wound dressings, PDRN soaked gauze dressing should be preferentially used for the treatment of fullthickness skin wounds.


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