Journal of the Korean Academy of Child and Adolescent Psychiatry

Korean Academy of Child and Adolescent Psychiatry (대한소아청소년정신의학회)
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Case-Control Association Study of the Norepinephrine Transporter Gene Polymorphism in Children with ADHD

주의력결핍 과잉행동장애와 노르에피네프린 수송체 유전자 다형성의 연관성

  • Song, Jung-Eun (Department of Psychiatry, Bundang Jesaeng Hospital) ;
  • Yook, Ki-Hwan (Department of Psychiatry, Bundang CHA Hospital, School of Medicine, CHA University) ;
  • Lee, Sung-Hee (Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, College of Medicine, Yonsei University) ;
  • Kim, So-Won (Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, College of Medicine, Yonsei University) ;
  • Lee, Min-Goo (Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, College of Medicine, Yonsei University) ;
  • Hong, Hyun-Ju (Department of Psychiatry, Hallym University College of Medicine)
  • 송정은 (분당 제생병원) ;
  • 육기환 (차의과학대학교 분당차병원 정신과학교실) ;
  • 이성희 (연세대학교 의과대학 약리학교실) ;
  • 김소원 (연세대학교 의과대학 약리학교실) ;
  • 이민구 (연세대학교 의과대학 약리학교실) ;
  • 홍현주 (한림대학교 의과대학 정신과학교실)
  • Received : 2009.09.30
  • Accepted : 2009.11.10
  • Published : 2010.03.30
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Abstract

Objectives ： This study aimed to examine the association between norepinephrine transporter gene (SLC6A2) polymorphisms and attention-deficit hyperactivity disorder (ADHD) and to examine the relationship between the genotypes and allele variants of SLC6A2 and results of the Korean version of the parent ADHD rating scale (K-ARS). Methods ： We examined the association between ADHD and norepinephrine transporter gene polymorphism using DNA from 137 Korean children with ADHD and 120 normal controls. We compared the genotype distributions and allele frequencies of SLC6A2 polymorphism between the control group and the ADHD group. Then, we correlated the children's K-ARS mean totals, inattention scores, and hyperactivity/impulsivity scores with the genotypes and alleles for each SLC6A2 polymorphism. Results ： There were no significant differences in genotype and allele distribution for each SLC6A2 polymorphism, as shown by the Chi-square test (p>.01). There was a trend toward a difference in allele frequency in rs 5568, but it was not statistically significant after adjusting for multiple comparisons (p=.048). Also, there were no significant differences in K-ARS scores according to the genotypes and alleles for the SLC6A2 polymorphisms. Conclusion ： Our study found no significant evidence of an association between SLC6A2 polymorphisms and ADHD.

Keywords

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