Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Development of Fast Dissolving Tablet Containing Herb Extract by Freeze-Drying Technique

  • Kim, Jae-Il (BK21 Project Team, College of Pharmacy, Chosun University) ;
  • Choi, Hoo-Kyun (BK21 Project Team, College of Pharmacy, Chosun University)
  • Received : 2010.04.13
  • Accepted : 2010.05.19
  • Published : 2010.06.20
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Abstract

A fast dissolving tablet was developed using the freeze-drying technique. Hyeonggaeyeongyotang was selected as a model oriental medicine. Formulation and processing parameters were studied to obtain freeze-dried tablet with high drug loading, good palatability, and fast disintegration time. $Kollidon^{(R)}$ CLM served as both matrix former and taste masking agent. Ethanol used as co-solvent, decreased the disintegration time of tablet. Aspartame was employed to impart better taste. Drying condition was found to have a major effect in the morphology of the tablets. Freeze-drying process was optimized to decrease the processing time and improve the appearance of the tablets.

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References

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