대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

순환기가감방(循環器加減方)이 고지혈증 유발 백서(白鼠)에 미치는 영향

Effect of Sunhwangigagambang(SHG) on Hyperlipidemia in SD Rats Induced by High Cholesterol Diet

  • 김동현 (대전대학교 한의과대학 심계내과학교실) ;
  • 임승민 (대전대학교 한의과대학 심계내과학교실) ;
  • 안정조 (대전대학교 한의과대학 심계내과학교실) ;
  • 조현경 (대전대학교 한의과대학 심계내과학교실) ;
  • 유호룡 (대전대학교 한의과대학 심계내과학교실) ;
  • 김윤식 (대전대학교 한의과대학 심계내과학교실) ;
  • 설인찬 (대전대학교 한의과대학 심계내과학교실)
  • Kim, Dong-Hyun (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Lim, Seung-Min (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Ahn, Jung-Jo (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Jo, Hyun-Kyung (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Yoo, Ho-Ryong (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Kim, Yoon-Sik (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Seol, In-Chan (Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University)
  • 발행 : 2010.09.30
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초록

Objective : This study was performed to investigate the effect of Sunhwangigagambang(SHG) on hyperlipidemia in SD rats induced by high cholesterol diet. Method : After treatment with SHG, cytotoxicity, body weight, liver weight, AST, ALT, ALP, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, albumin, total protein in serum, malondialdehyde, and gene expression for ACAT and HMG-CoA reductase in hepatic tissue were analyzed. Result : 1. SHG didn't show any cytotoxicity in both human fibroblast cell line and SD rats. 2. SHG significantly inhibited the increase of liver weight by high cholesterol diet compared to the control group. 3. SHG significantly ameliorated the increase of total cholesterol, LDL-cholesterol, and triglyceride and reduction of HDL-cholesterol compared to the control group. 4. SHG significantly reduced glucose level in serum compared to the control group. 5. SHG significantly reduced malondialdehyde in hepatic tissue compared to the control group. 6. SHG significantly down-regulated gene expression of ACAT and HMG-CoA reductase compared to the control group. Conclusion : These results suggest that SHG might be effective in treatment and prevention of hyperlipidemia.

키워드

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