Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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New Paradigms in the Pathogenesis of Chronic Obstructive Pulmonary Disease

만성 폐쇄성 폐질환의 새로운 병인

  • Kim, Hui-Jung (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sanbon Medical Center, Wonkwang University School of Medicine)
  • 김휘정 (원광대학교 의과대학 산본병원 호흡기내과학교실)
  • Received : 2010.06.02
  • Accepted : 2010.06.02
  • Published : 2010.11.30
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Abstract

A key mechanism in the pathogenesis of chronic obstructive pulmonary disease is thought to be an abnormal inflammatory response in the lungs to the inhalation of toxic particles and gases, derived from tobacco smoke, air pollution, and/or occupational exposures. This review highlights the potential participation of several alternative pathogenetic processes, particularly involving the potential participation of biological and pathobiological processes related to aging, including oxidative stress and enhanced expression of markers of senescence/aging in emphysematous lungs, and the potential for enhanced tissue destruction involving alveolar cell apoptosis.

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