Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Isolation of Hepatoprotective Phenylpropanoid from Lactuca indica

  • Kim, Ki-Hyun (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Young-Ho (Microbiology Laboratory, College of Natural Sciences, Dept. of Life Science, The University of Suwon) ;
  • Lee, Kang-Ro (Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University)
  • Received : 2010.01.28
  • Accepted : 2010.03.06
  • Published : 2010.03.31
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Abstract

In continuing our search for biologically active compounds from Korean Compositae medicinal plants, we investigated the constituents of the aerial parts of Lactuca indica L. and isolated a phenylpropanoid derivative from its MeOH extract. The chemical structure was characterized by spectroscopic methods, including 1D and 2D NMR to be di-E-caffeoyl-meso-tartaric acid (1). Compound 1 was isolated for the first time from this plant. In this paper, we suggest that the NMR assignment at C-2 of (+)-taraxafolin-B should be corrected. In the human HBV-transfected liver cell line HepG2.2.15, the compound 1 effectively reduced HBV DNA level in the release of mature HBV particles from HepG2.2.15 cultivation.

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References

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