한약치료가 Angiotensin Converting Enzyme Inhibitor를 복용중인 고혈압환자에게 부작용으로 나타나는 건해(乾咳)에 미치는 영향

Effects of Herb Medication on Dry Cough, a Common Side Effect Caused by Angiotensin Converting Enzyme (ACE) Inhibitor

  • 김현진 (국립의료원 한방진료부 한방내과) ;
  • 강래엽 (국립의료원 한방진료부 한방내과) ;
  • 한효정 (국립의료원 한방진료부 한방내과) ;
  • 박은영 (국립의료원 한방진료부 한방내과) ;
  • 장정아 (국립의료원 한방진료부 한방내과) ;
  • 서호석 (국립의료원 한방진료부 한방내과) ;
  • 박소애 (대전대학교 한의과대학 심계내과학교실) ;
  • 김진원 (국립의료원 한방진료부 한방내과)
  • Kim, Hyun-Jin (Department of Oriental Internal Medicine, National Medical Center) ;
  • Kang, Rae-Yeop (Department of Oriental Internal Medicine, National Medical Center) ;
  • Han, Hyo-Jung (Department of Oriental Internal Medicine, National Medical Center) ;
  • Park, Eun-Young (Department of Oriental Internal Medicine, National Medical Center) ;
  • Jang, Jeong-A (Department of Oriental Internal Medicine, National Medical Center) ;
  • Seo, Ho-Seok (Department of Oriental Internal Medicine, National Medical Center) ;
  • Park, So-Ae (Division of Circulatory System, Dept. of Internal Medicine, College of Oriental Medicine, Dae-jeon University) ;
  • Kim, Jin-Won (Department of Oriental Internal Medicine, National Medical Center)
  • 투고 : 2009.07.24
  • 심사 : 2009.09.01
  • 발행 : 2010.01.30

초록

Objectives: In order to confirm a remedial effect and related influence of the clinic treatment by prescribing herb medicines to hypertensives experiencing angiotensin converting enzyme (ACE) inhibitor dosage and suffering from common side effect generally known as dry cough. Methods: 1. We selected the 19 patients who visited National Oriental Medical Center, from August 21, 2007 to August 16, 2008 and suffering from dry cough caused by taking ACE inhibitor, with no other possible diseases causing dry cough. 2. We separated the 19 patients into two groups (Type 1: Bi-Qi hie (脾氣虛) group prescribed Samchuljojung-tang & Type 2: Qi-hie dam-wul (氣虛痰鬱) group prescribed Samsoumgamibang). 3. We then observed the symptom level and post-treatment effect, and recorded changes of dry cough intensity level for each group. Results: 1. Type 1: In the survey of 12 patients, initial level recorded 16.33 at entry diagnosis, and next level meant changing of symptoms, recorded as 2.75 at Stage 1 and reaching 3.33 at Stage 2. 2. Type 2: 7 patients, with initial level recorded as 18.71 at entry diagnosis, and 1.86 at Stage 1 and reaching to 3.29 at Stage 2. 3. No additional prescriptions were issued at Stage 2 or afterwards, and final result indicates that the mean value ended at 3.95 in the total group. Conclusions: It is concluded that there is a significant remedial effect and related influence of the clinic treatment between the Oriental medicine treatment and one of the common side effects of ACE inhibitor, dry cough.

키워드

참고문헌

  1. Braunwald E, Fauci A, Kasper D, Hauser S, Longo D, Jameson J. Harrison's Principles of Internal Medicine Vol2. 16th ed. Seoul:MIP. 2006:1596.
  2. Howland DR, Mycek JM. Lippincott's Illustrated Reviews : pharmacology. 3rd ed. USA: Lippincott Williams and Wilkins. 2006: 213.
  3. Kim JH, Jeong HC, Kim KK, Lee SY, Kwon YH, Lee SR, et al. Correlation Between Angiotensin- Converting Enzyme (ACE) Inhibitor Induced Dry Cough and ACE Gene Insertion / Deletion (I/D) Polymorphism. The Korean Academy of Tuberculosis and Respiratory Disease. 1999;46(2):242-50.
  4. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Ann Intern Med. 1992:117 (3),234-242. https://doi.org/10.7326/0003-4819-117-3-234
  5. Os I, Bratland B, Dahlof B, Gisholt K, Syvertsen JO, Tretli S. Female sex as an important determinant of lisinopril-induced cough. Lancet. 1992;339:372
  6. Sebastian JL, Mckinney WP, Kaufman J, Young MJ. Angiotensin converting enzyme inhibitors and cough: prevalence in an outpatient medical clinic population. Chest. 1991;99: 36. https://doi.org/10.1378/chest.99.1.36
  7. Stoller JK, Elghazawi A, Mehta AC, Vidt DC. Captopril-induced cough. Chest. 1988;93(3):659 https://doi.org/10.1378/chest.93.3.659
  8. Kim SJ, Lee BR. Bibilographic Study on the Classification Methods of the Cause of Disease and the Acupuncture Points on the Cough. Taejon University Research Institute of Korean Medicine. 2000;9(1):423
  9. College of Oriental Medicine of Respiratory System. Oriental Internal Medicine of Respiratory System. Seoul: Nado. 2007:143-177.
  10. Heo J. Dongeuibogam. Seoul: Bubin-Publishers. 1999:1241
  11. College of Oriental Medicine of Gastrointestinal System. Oriental Internal Medicine of Gastrointestinal System. Seoul: Artgongbang. 1998:37.
  12. Shin JY, Bangyakhappyeon-haesul, Seoul:Oriental Medical Institute. 1988:118-119.
  13. Jung MK, Hong SJ, Lee SH, Hong SJ, Song JW, Kang WS, et al. Development and Validation of a Korean Allergic Rhinitis-Specific Quality of Life Questionnaire(KARQLQ). Korean J Asthma Allergy Clin Immunol. 2008;28(2):113-120.
  14. Jung JY, Song JY, Hong SJ, Lee YW, Sin YS, Park JW, et al. Comparison of the Patients Global Self-Assessment scoring Method with the Quality of Life Questionnaire for Adult Korean Asthmatics. Korean J Asthma Allergy Clin Immunol. 2008;28(2):132-142.
  15. Neal JM. Medical pharmacology at a glance. 5th ed. UK: Blackwell Publishing. 2005: 36.
  16. Han SH, Ryu DG, Lee DJ. Effects of Samchuljojungtang and Samchuljojungtang add Samyotang Water Extract on the Plasma Cortisol Concentration in the Rabbit. Korean Journal of Oriental Medical Pathology. 1999;3:89-99
  17. Li C. Singyu pyunju Yixuerumen. Vol2. Seoul: DaeSung-munhwasa. 1994:141.
  18. Jin SM. Taepunghyemin-whajeguggang. Vol2. Taipei: Sunpoong. 1964: 8.
  19. Yoon GY. Oriental Clinic Formula study. Seoul: Myungbo. 1992:521.
  20. College of Oriental Medicine, A Herbal Medicine lecture room. Herbology. Seoul: Yungrimsa. 2000:478,484,587.