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토착미생물 발효물인 CS682의 급여가 닭과 돼지의 생산성에 미치는 영향

Effects of CS682, a Fermentation Product of Korean Soil Bacteria, on Growth Performance in Chickens and Pigs

  • Kim, Hu-Kyung (Livestock and Veterinary Service) ;
  • Kim, Se-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Shim, Kyung-Mi (Department of Radiology, Nambu University) ;
  • Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University) ;
  • Choi, Seok-Hwa (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University)
  • 투고 : 2009.11.26
  • 심사 : 2010.01.13
  • 발행 : 2010.02.28

초록

CS682의 육계 및 이유자돈에서 사료첨가제로서의 기능성을 검정하기 위해 병아리에 28일간 0.1%, 1%의 농도로 사료에 첨가, 급여하여 질병예방기능, 성장기능, 사료효율기능 및 안전성 평가를 실시한 결과, 위장관계 기능 장애를 일으키지 않고, 생체대사에 영향을 미치지 않으면서 사료효율을 높이는 것으로 나타났다. CS682 투여 후 14일째에는 각 군 간에 증체량 및 사료효율에서 차이가 미미하였으나, 28일째에는 대조군에 비해 0.1%군은 115.64, 1%군은 122.49%의 사료효율을 보여 각 군 간에 큰 차이를 나타내었다. 그리고 28일째 각 군에서 채혈한 혈액의 기본 혈구검사를 실시한 결과 각 군 간에 유의적인 차이를 보이지 않고 모두 정상 범위를 나타낸 것으로 보아 CS682는 생체대사에 영향을 미치지 않는 것으로 보인다. 또한 이유자돈에서 28일간 0.1%의 농도로 사료에 첨가, 급여하여 질병예방기능, 성장기능, 사료효율기능 및 안전성 평가를 실시한 결과에서 임상적으로 특이한 부작용 없이 대조군에 비하여 높은 사료효율을 나타냈다. 결론적으로 육계와 이유자돈에서 CS682의 사료첨가는 생체대사에 영향을 미치지 않고, 소화기 이상 증상을 유발하지도 않으면서 사료효율을 효과적으로 증가시키는 것으로 나타났다. 본 결과를 토대로 육계 및 이유자돈에서 안전하게 증체율 및 사료효율을 증가시킬 목적으로 CS682를 사료에 첨가하는 것이 효과적일 것으로 생각된다.

Antibiotics in veterinary medicine have been used to treat disease, promote growth rate and improve feed efficiency. However, alternative sources are needed because of of bacterial resistance to antibiotics and residues of antibiotics. The present study was carried out to evaluate the effect of CS682, a fermentation product of Korean soil bacteria, on safety, growth rate and feed efficiency, and to evaluate its value as an alternative for antibiotics used as a feed additive. Two dosages of CS682 (0.1% and 1%) were fed to chickens for 28 days. The results showed that, when compared to chickens in the control group, growth and feed efficiency was improved. Also, mortality, hematology, general clinical signs and necropsy were examined. Chickens in the treatment groups showed no adverse effects. A total of 72 weaning pigs were used to confirm the effects of CS682 at one dose level (0.1%) regarding feed efficiency. Supplementation with 0.1% CS682 also resulted in improved weight gain and feed efficiency ratio. Based on these results, CS682 may be effective in improving feed efficiency safely as a feed additive.

키워드

참고문헌

  1. Addison, J. B. 1984. Antibiotics in sediments and run-off waters from feedlots. Residue Rev. 92, 1-24.
  2. AHI (Animal Health Institute). 2002. http://www.ahi.org/.
  3. Caspar, W. 2005. Herbs and botanicals as feed additives in monogastric animals. Asian-Aust. J. Anim. Sci. 16, 282-289.
  4. Chen, Y. J., K. S. Son, B. J. Min, J. H. Cho, O. S. Kwon, and I. H. Kim. 2005. Effects of dietary probiotic on growth performance, nutrients digestibility, blood characteristics and fecal noxious gas content in growing pigs. Asia-Aust. J. Anim. Sci. 18, 1464-1468. https://doi.org/10.5713/ajas.2005.1464
  5. Chiang, S. H. and W. M. Hsieh. 1995. Effect of direct-fed microorganisms on broiler growth performance and litter ammonia level. Asian-Aust. J. Anim. Sci. 8, 159-162. https://doi.org/10.5713/ajas.1995.159
  6. Cho, S. S., J. K. Sohng, H. J. Lee, S. J. Park, J. R. Simkhadal, and J. C. Yoo. 2009. Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by high performance liquid chromatography. Arch. Pharm. Res. 32, 335-340, https://doi.org/10.1007/s12272-009-1304-0
  7. Cromwell, G. L. 2002. Why and how antibiotics are used in swine production. Anim. Biotechnol. 13, 7-27. https://doi.org/10.1081/ABIO-120005767
  8. Dewey, C. E., B. D. Cox, B. E. Straw, E. J. Bush, and H. S. Hurd. 1997. Associations between off-label feed additives and farm size, veterinary consult use, and animal age. Prev. Vet. Med. 31, 133-146. https://doi.org/10.1016/S0167-5877(96)01077-X
  9. Dewey, C. E., B. D. Cox, B. E. Straw, E. J. Bush, and H. S. Hurd. 1999. Use of antimicrobials in swine feeds in the United States. Swine Health Prod. 7, 19-25.
  10. Florea, N. F. and C. H. Nightingale. 2004. Review of the pharmacodynamics of antibiotic use in animal food production. Diagn. Microbiol. Infect. Dis. 49, 105-108. https://doi.org/10.1016/j.diagmicrobio.2003.12.007
  11. Fuller, R. 1989. Probiotics in man and animals, a review. J. Appl. Bacterol. 66, 365-378. https://doi.org/10.1111/j.1365-2672.1989.tb05105.x
  12. Han, I. K., B. J. Chae, and S. K. Kim. 1983. The effects of feeding milk fermentation by-product and probiotics on the growing performance and prevention of diarrhea of the growing pigs. Kor. J. Anim. Sci. 25, 146-152.
  13. Hill, I. R., R. Kenworthy, and P. Porter. 1970. Studies of the effect of dietary lactobacilli on intestinal and urinary amines in pigs in relation to weaning and postweaning diarrhea. Res. Vet. Sci. 11, 320-326.
  14. Hong, J. W., I. H. Kim, I. H. Hwang, J. H. Lee, J. H. Kim, O. S. Kwon, and S. H. Lee. 2003. Evaluation of recombinant human lactoferricin culture as a substitute for antibiotic in pig starter diets. J. Anim. Sci. & Tech. 45, 537-542. https://doi.org/10.5187/JAST.2003.45.4.537
  15. Hong, J. W., I. H. Kim, O. S. Kwon, J. H. Kim, B. J. Min, and W. B. Lee. 2002. Effects of dietary probiotics supplementation on growth performance and fecal gas emission in nursing and finishing pigs. J. Anim. Sci. & Tech. 44, 305-314. https://doi.org/10.5187/JAST.2002.44.3.305
  16. Jeon, B. S., J. H. Kwag, Y. H. Yoo, J. O. Cha, and H. S. Park. 1996. Effects of feeding enzymes, probiotics or yucca powder on pig growth and odor-generating substances in feces. Kor. J. Anim. Sci. 38, 52-58.
  17. Jin, L. Z., Y. W. Abdullah, and S. Jalaludin. 1998. Growth perfrmance, intestinal microbial populations, and serum cholesterol of broilers fed diets containing lactobacillus cultures. Poult. Sci. 77, 1259-1265. https://doi.org/10.1093/ps/77.9.1259
  18. Kanfer, I., M. F. Skinner, and R. B. Walker. 1998. Analysis of macrolide antibiotics. J. Chromatogr. A 812, 25-286.
  19. Kim, S. H., J. C. Yoo, and T. S. Kim. 2009. Nargenicin enhances 1,25-dihydroxyvitamin D3-and all-trans retinoic acid-induced leukemia cell differentiation via PKC$\beta$ I/MAPK pathways. Biochem. Pharm. 77, 1694-1701. https://doi.org/10.1016/j.bcp.2009.03.004
  20. Lee, J. C., T. H. Ahn, S. S. Kang, C. J. Moon, C. S. Bae, S. H. Kim, J. C. Yoo, and J. C. Kim. 2007. Single oral dose toxicity evaluation of CS682, a fermentation product of Korean soil bacteria, in rats. Lab. Anim. Res. 23, 401-404.
  21. MIFAFF (Ministry of Food, Agriculture, Forestry and Fisheries). 2008, http://www.mifaff.go.kr/main.tdf.
  22. Min, B. J, and I. H. Kim. 2002. Effect of dietary probiotics supplementation to feed for monogastric animals. Kor. J. Org. Agri. 10, 47-60.
  23. Murray, B. 1995. What can we do about vancomycin-resistant enterococci? Clin. Infect. Dis. 20, 1134-1136. https://doi.org/10.1093/clinids/20.5.1134
  24. NASS (National Agricultural Statistics Service). 2002. http://www.usda.gov/nass.
  25. National veterinary research and quarantine service. Guidelines on animal medical supplies for formula feed production. Public Notice No 2008-25, Anyang, Korea.
  26. Owings, W. J., D. L. Reynolds, R. J. Hasiak, and P. R. Ferket. 1990. Influence of dietary supplementation with Streptococcus facecium M-74 on broiler body weight, feed conversion, carcass characteristics and intestinal microbial colonization. Poult. Sci. 69, 1257-1264.
  27. Pollmann, D. S., D. M. Danielson, and E. R. Peo, Jr. 1980. Effects of microbial feed additives on performance of starter and growing-finishing pigs. J. Anim. Sci. 51, 577-581.
  28. Shin, I. S., J. C. Lee, N. H. Park, S. S. Kang, C. J. Moon, S. H. Kim, J. C. Yoo, and J. C. Kim. 2009. Subacute toxicity study of CS682, a fermentation product of Korean soil bacteria, in rats. Lab. Anim. Res. 25, 7-13.
  29. Sohng, J. K., T. Yamaguchi, C. N. Seong, K. S. Baik, S. C. Park, H. J. Lee, S. Y. Jang, J. R. Simkhada, and J. C. Yoo. 2008. Production, isolation and biological activity of nargenicin from Nocardia sp. CS682. Arch. Pharm. Res. 31, 1339-1345. https://doi.org/10.1007/s12272-001-2115-0
  30. Underdahl, N. R., A. Torres-Medina, and A. R. Dosten. 1982. Effect of Streptococcus faecium C-68 in control of Escherichia coli-induced diarrhea in gnotobiotic pigs. Am. J .Vet. Res. 43, 2227-2232.
  31. Watkins, B. A. and F. H. Kratzer. 1984. Drinking water treatment with a commercial preparation of a concentrated Lactobacillus culture for broiler chickens. Poult. Sci. 63, 1671-1673. https://doi.org/10.3382/ps.0631671
  32. Xuan, Z. N, J. D. Kim, K. N. Heo, H. J. Jung, J. H. Lee, Y. K. Han, Y. Y. Kim, and I. K. Han. 2001. Study on the development of a probiotics complex for weaned pigs. Asian-Aust. J. Anim. Sci. 14, 1425-1428. https://doi.org/10.5713/ajas.2001.1425

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