The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Studies on the Inhibitory Effect of Berberidis Ramulus to the Liver Cancer

소벽(小檗)의 간암 억제효과에 대한 연구

  • Lee, Chung-Heon (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Han, Hyo-Sang (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • 이충헌 (경원대학교 한의과대학 본초학교실) ;
  • 한효상 (경원대학교 한의과대학 본초학교실) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Received : 2010.11.06
  • Accepted : 2010.12.15
  • Published : 2010.12.30
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Abstract

Objectives : This study purposed to research the inhibitory effect of Berberidis Ramulus on the liver cancer. Methods : A total extract of Berberidis Ramulus decoction were prepared. Through the measurement of the cell proliferation, apoptosis, morphology and cytokine level from the extracts, the influence on HepG2 cell were compared. Results : Berberidis Ramulus extract significantly inhibited the proliferation, increased the apoptosis, decreased the TGF-${\beta}$ gene expression and the K-RAS gene expression, significantly increased the level of TNF-${\alpha}$ secretion and increased the rates of IFN-${\gamma}$ secretory cells. Conclusion : It is suggested that Berberidis Ramulus extract turned out to have anti-cancer effects on HepG2 cell.

Keywords

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