Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments

  • Han, Jung-Ho (Department of Neurosurgery, Seoul National University Bundang Hospital) ;
  • Kim, Dong-Gyu (Department of Neurosurgery, Seoul National University Hospital) ;
  • Park, Jung-Cheol (Department of Neurosurgery, Jeju University Hospital) ;
  • Chung, Hyun-Tai (Department of Neurosurgery, Seoul National University Hospital) ;
  • Paek, Sun-Ha (Department of Neurosurgery, Seoul National University Hospital) ;
  • Chung, Young-Seob (Department of Neurosurgery, Seoul National University Boramae Hospital)
  • Received : 2010.01.13
  • Accepted : 2010.05.10
  • Published : 2010.05.28
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Abstract

Objective : We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC). Methods : Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 ${\pm}$ 13 years, and 17 (85.0%) were men. Seventeen (85.0%) patients had already extracranial metastases. The median time from diagnosis of HCC to brain metastasis was 18.5 months. Fourteen (70.0%) patients had stroke-like presentation due to intracerebral hemorrhage (ICH). Ten (50.0%) patients had single or solitary brain metastasis. Among a total of 34 brain lesions, 31 (91.2%) lesions had the hemorrhagic components. Results : The median survival time was 8 weeks (95% CI, 5.08-10.92), and the actuarial survival rates were 85.0%, 45.0%, 22.5%, and 8.4% at 4, 12, 24, and 54 weeks. Age < 60 years, treatment of the primary and/or extracranial lesions, and recurrent ICH were the possible prognostic factors (p = 0.044, p < 0.001, and p = 0.111, respectively). The median progression-free survival (PFS) time was 3 months (95% CI, 0.95-5.05). Conclusion : The overall survival of the patients with brain metastasis from HCC was very poor with median survival time being only 8 weeks. However, the younger patients less than 60 years and/or no extracranial metastases seem to be a positive prognostic factor.

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References

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