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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics

  • Park, Byung-Lae (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Park, Se-Min (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Park, Jong-Sook (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Uh, Soo-Taek (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Choi, Jae-Sung (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Kim, Yong-Hoon (Division of Internal Medicine, Chungbuk National University, College of Medicine) ;
  • Kim, Mi-Kyeong (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences) ;
  • Choi, In-Seon S. (Division of Pulmonology and Allergy, Department of Internal Medicine, Chung-Ang University Yongsan Hospital) ;
  • Choi, Byoung-Whui (Department of Internal Medicine and Institute of Allergy and Clinical Immunology, Seoul National University College of Medicine) ;
  • Cho, Sang-Heon (Division of Allergy and Immunology, Institute of Allergy, Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Hong, Chein-Soo (Pulmonary, Allergy & Critical Care Medicine, Hallym University College of Medicine) ;
  • Lee, Yong-Won (Pulmonary, Allergy & Critical Care Medicine, Hallym University College of Medicine) ;
  • Lee, Jae-Young (Department of Life Science, Sogang University) ;
  • Park, Choon-Sik (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital) ;
  • Shin, Hyoung-Doo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
  • Received : 2010.02.01
  • Accepted : 2010.05.07
  • Published : 2010.06.30
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Abstract

Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After genotyping 120 SNPs of the PTGER gene family for the $1^{st}$ cohort study, four SNPs in PTGER1, ten in PTGER3, six in PTGER3, and a haplotype of PTGER2 showed association signals with decreased or increased risk of AIA. Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the $2^{nd}$ cohort study. The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the $2^{nd}$ cohort study. Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics.

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References

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