Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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An Expeditious Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines to Pyridines Using Cetyltrimethylammonium Peroxodisulfate: A Phase Transferring Oxidant

  • Kumar, Parvin (Chemistry Department, Guru Nanak Khalsa College) ;
  • Kumar, Ashwani (Drug discovery and research laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology)
  • Received : 2010.05.22
  • Accepted : 2010.06.26
  • Published : 2010.08.20
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Abstract

A new approach to the use of potassium peroxodisulphate as an oxidizing reagent is proposed and applied to the case of oxidative aromatization of 1, 4-dihydropyridines with cetyltrimethylammonium peroxodisulfate, a phase transfer oxidant. We demonstrate how it is possible to increase the reactivity of potassium peroxodisulphate in the presence of phase transfer catalyst. Dealkylation in case of 4-n-alkyl/n-alkenyl was not obtained.

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References

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