Korean Journal of Oriental Medicine (한국한의학연구원논문집)

Korean Institute of Oriental Medicine (한국한의학연구원)
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Methanolic extract from the root of Bupleuri falcatum L. attenuates cocaine-induced c-Fos expression in rat brain.

시호 메탄올 추출물이 코카인 약물중독에 의한 흰쥐 뇌의 c-Fos 발현에 미치는 영향

  • Choi, Seong-Hun (Dept. of Anatomy and Histology, College of Oriental Medicine, Daeggu Haany Univ.) ;
  • Ku, Sae-Kwang (Dept. of Anatomy and Histology, College of Oriental Medicine, Daeggu Haany Univ.) ;
  • Han, Chang-Hyun (TKM Information Research Division, Korea Institute of Oriental Medicine) ;
  • Yang, Chae-Ha (Dept. of Physiology, College of Oriental Medicine, Daegu Haany Univ.)
  • 최성훈 (대구한의대학교 한의과대학 해부학교실) ;
  • 구세광 (대구한의대학교 한의과대학 해부학교실) ;
  • 한창현 (한국한의학연구원 문헌연구센터) ;
  • 양재하 (대구한의대학교 한의과대학 생리학교실)
  • Received : 2010.02.27
  • Accepted : 2010.03.25
  • Published : 2010.04.30
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Abstract

Objectives : The aim of present study is to examine the effect of methanolic extract from the root of Bupleurum falcatum L. (BF) on acute cocaine-induced c-Fos expression in the rat caudate putamen (CPu), a major dopaminergic terminal. Methods : Male Sprague-Dawley rats were subjected to an intraperitoneal injection with either cocaine hydrochloride (20 mg/kg) or saline 30 min after an administration of either extract of BF (100 mg/kg, i.p.) or vehicle. Animals were sacrificed 2 hr after treatment with cocaine or saline for immunohistochemistry. Quantification of brain slices was examined for c-Fos positive nuclei using light microscopy. Results : Pretreatment with BF significantly attenuated cocaine-induced c-Fos expression in the rat CPu. Conclusions : This finding suggests that BF has the inhibitory effect on cocaine-induced c-Fos expression in the rat CPu via possibly modulating the activities of central dopaminergic systems.

Keywords

References

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