The Korean Journal of Applied Statistics (응용통계연구)

The Korean Statistical Society (한국통계학회)
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Statistical Interaction for Major Gene Combinations

우수 유전자 조합 선별을 위한 통계적 상호작용 방법비교

  • Received : 20100200
  • Accepted : 20100700
  • Published : 2010.08.31
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Abstract

Diseases of human or economical traits of cattles are occured by interaction of genes. We introduce expanded multifactor dimensionality reduction(E-MDR), dummy multifactor dimensionality reduction(D-MDR) and SNPHarvester which are developed to find interaction of genes. We will select interaction of outstanding gene combinations and select final best genotype groups.

대개 인간의 질병과 관련된 유전자나 가축의 경제적인 특성과 관련된 유전자는 주로 상호작용으로 일어난다. 유전자의 상호작용을 찾기 위한 방법으로 다양한 방법들이 제시되었다. 본 논문에서는 유전자의 상호작용 효과를 규명하기 위해 개발된 확장된 MDR방법(E-MDR)과 더미변수를 활용한 MDR방법(D-MDR), 대규모 유전자들 중에서 주요 유전자 조합을 선별하는 SNPHarvester방법을 비교하여 인간의 질병이 아닌 한우의 경제적인 특성에 적용하여 우수한 유전자 조합을 선별하고 우수 유전자형을 밝힌다.

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References

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